Bookmarking target genes in mitosis: A shared epigenetic trait of phenotypic transcription factors and oncogenes?

Sayyed K. Zaidi, Rodrigo A. Grandy, Cesar Lopez-Camacho, Martin Montecino, Andre J. Van Wijnen, Jane B. Lian, Janet L. Stein, Gary S. Stein

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

The regulatory information for phenotype, proliferation, and growth of normal and tumor cells must be maintained through genome replication in the S phase and cell division during mitosis. Epigenetic mechanisms that include DNA methylation, posttranslational modifications of histones, selective utilization of histone variants, and inheritable RNA molecules play pivotal roles in maintaining cellular identity through mitotic divisions. Recent studies demonstrate that mitotic occupancy of genes, which are determinants of cell fate, growth, and proliferation, by lineage-restricted transcription factors is a key epigenetic mechanism for retention and transmission of cellular expression memory. Evidence is emerging for the presence of distinct transcriptional regulatory microenvironments in mitotic chromosomes in which the genes bookmarked for reactivation postmitotically reside. Importantly, some oncoproteins are present in mitotic microenvironments where they occupy target genes during mitosis and may contribute to perpetuating the transformed phenotype. We discuss emerging regulatory implications of epigenetically bookmarking genes during mitosis for physiologic control as well as for the onset and progression of cancer.

Original languageEnglish (US)
Pages (from-to)420-425
Number of pages6
JournalCancer research
Volume74
Issue number2
DOIs
StatePublished - Jan 15 2014

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Zaidi, S. K., Grandy, R. A., Lopez-Camacho, C., Montecino, M., Van Wijnen, A. J., Lian, J. B., Stein, J. L., & Stein, G. S. (2014). Bookmarking target genes in mitosis: A shared epigenetic trait of phenotypic transcription factors and oncogenes? Cancer research, 74(2), 420-425. https://doi.org/10.1158/0008-5472.CAN-13-2837