Bone morphogenetic proteins and bone morphogenetic protein gene therapy in neurological surgery: A review

Gregory A. Helm, Tord D. Alden, Jason P. Sheehan, David Kallmes

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations

Abstract

OBJECTIVE: To review the uses of bone morphogenetic proteins (BMPs) and BMP gene therapy for the treatment of neurosurgical disorders. METHODS: Literature review. RESULTS: BMPs are members of the transforming growth factor β superfamily, and they play an important role in the growth and development of numerous tissues, including bone, brain, and spinal cord. Although the majority of previous studies have focused on the regulatory functions of BMPs in the normal growth and differentiation of the skeletal system, BMPs also seem to be exquisitely involved in the regulation of cellular proliferation, survival, differentiation, apoptosis, and lineage commitment in the central nervous system. When specific BMPs are delivered on biological matrices, they have the capacity to induce bone, cartilage, ligament, and tendon at both heterotopic and orthotopic sites, suggesting that they may play a major role in the future treatment of spinal and craniofacial pathology. For example, recent studies have clearly demonstrated the usefulness of BMPs and BMP gene therapy for the induction of spinal arthrodesis in several animal models. In addition, several BMPs have been shown to have a neuroprotective effect in animal models of head injury, cerebral ischemia, and Parkinson's disease and may therefore have direct clinical applications for the treatment of central nervous system disorders. CONCLUSION: As the physiological activity of BMPs in the development and pathology of the central nervous system and spine are more fully elucidated, BMP therapeutics and gene therapy will probably have numerous applications in neurological surgery.

Original languageEnglish (US)
Pages (from-to)1213-1222
Number of pages10
JournalNeurosurgery
Volume46
Issue number5
DOIs
StatePublished - May 2000

Keywords

  • Bone morphogenetic proteins
  • Gene therapy
  • Head injury
  • Spinal fusion
  • Stroke

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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