@inproceedings{41b6c7f6e6b9407287f85ffe2ce75f03,
title = "Bone metabolism in rat tibia is regulated by sex steroids",
abstract = "Our research provides evidence that sex steroids are important regulators of bone metabolism in rats. These hormones are essential for the sexual dimorphism of the skeleton during growth and cancellous bone balance in adults. All three major classes of sex steroids - estrogens, androgens and progestins - appear to influence bone metabolism and may interact with one another to generate a fine control over bone cells. The response of the tibia to sex steroids is compartment-specific and further studies will be necessary to determine whether the results obtained in tibiae can be generalized to the skeleton as a whole. The mechanisms of action of sex steroids on bone are unknown but new technology enabling quantitation of the mRNA's for bone cell proteins and growth factors expressed in vivo should provide new insights into possible regulation of gene expression in skeletal tissues by these hormones.",
author = "Turner, {R. T.} and Colvard, {D. S.} and B. Bleiberg and G. Evans and R. Francis and Spelsberg, {T. C.}",
year = "1990",
language = "English (US)",
isbn = "0444813292",
series = "Calcium regulation and bone metabolism. Basic and clinical aspects: proceedings of the 10th International Conference on calcium regulating hormones and bone metabolism. ICS886",
publisher = "Elsevier Science Publishers B.V.",
pages = "448--454",
editor = "D.V. Cohn and F.H. Glorieux and T.J. Martin and D.V. Cohn and F.H. Glorieux and T.J. Martin",
booktitle = "Calcium regulation and bone metabolism. Basic and clinical aspects",
note = "The 10th International Conference on calcium regulating hormones and bone metabolism ; Conference date: 09-09-1989 Through 14-09-1989",
}