Bone metabolism in rat tibia is regulated by sex steroids

R. T. Turner, D. S. Colvard, B. Bleiberg, G. Evans, R. Francis, T. C. Spelsberg

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Our research provides evidence that sex steroids are important regulators of bone metabolism in rats. These hormones are essential for the sexual dimorphism of the skeleton during growth and cancellous bone balance in adults. All three major classes of sex steroids - estrogens, androgens and progestins - appear to influence bone metabolism and may interact with one another to generate a fine control over bone cells. The response of the tibia to sex steroids is compartment-specific and further studies will be necessary to determine whether the results obtained in tibiae can be generalized to the skeleton as a whole. The mechanisms of action of sex steroids on bone are unknown but new technology enabling quantitation of the mRNA's for bone cell proteins and growth factors expressed in vivo should provide new insights into possible regulation of gene expression in skeletal tissues by these hormones.

Original languageEnglish (US)
Title of host publicationCalcium regulation and bone metabolism. Basic and clinical aspects
Subtitle of host publicationproceedings of the 10th International Conference on calcium regulating hormones and bone metabolism. ICS886
EditorsD.V. Cohn, F.H. Glorieux, T.J. Martin, D.V. Cohn, F.H. Glorieux, T.J. Martin
PublisherElsevier Science Publishers B.V.
Pages448-454
Number of pages7
ISBN (Print)0444813292
StatePublished - Jan 1 1990
EventThe 10th International Conference on calcium regulating hormones and bone metabolism -
Duration: Sep 9 1989Sep 14 1989

Publication series

NameCalcium regulation and bone metabolism. Basic and clinical aspects: proceedings of the 10th International Conference on calcium regulating hormones and bone metabolism. ICS886

Other

OtherThe 10th International Conference on calcium regulating hormones and bone metabolism
Period9/9/899/14/89

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Turner, R. T., Colvard, D. S., Bleiberg, B., Evans, G., Francis, R., & Spelsberg, T. C. (1990). Bone metabolism in rat tibia is regulated by sex steroids. In D. V. Cohn, F. H. Glorieux, T. J. Martin, D. V. Cohn, F. H. Glorieux, & T. J. Martin (Eds.), Calcium regulation and bone metabolism. Basic and clinical aspects: proceedings of the 10th International Conference on calcium regulating hormones and bone metabolism. ICS886 (pp. 448-454). (Calcium regulation and bone metabolism. Basic and clinical aspects: proceedings of the 10th International Conference on calcium regulating hormones and bone metabolism. ICS886). Elsevier Science Publishers B.V..