Bone marrow histopathology in peripheral T-cell lymphomas

Ahmet Dogan, William G. Morice

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Peripheral T-cell lymphomas (PTCL) account for 10-15% of all lymphoproliferative disorders in the western hemisphere. In PTCL, bone marrow biopsy is performed to establish the diagnosis, rule out other pathology, assess the extent of disease and monitor treatment response. The frequency and histology of bone marrow involvement varies greatly between different clinicopathological entities recognized by the World Health Organisation (WHO) classification, reflecting the differences in the underlying biology. Some lymphomas, such as angioimmunoblastic T-cell lymphoma, show nodular and/or interstitial pattern of infiltration with accompanying reactive changes. Others, including hepatosplenic T-cell lymphoma and large granular lymphocyte leukaemia, are characterized by intrasinusoidal infiltration. In many instances the pathological features are subtle and immunohistochemical and molecular studies are required for the diagnosis. Histological appearances may overlap with a variety of reactive T-cell proliferations and other malignancies. Furthermore PTCL frequently induce secondary changes in the marrow that may obscure the neoplastic infiltrate. The diagnosis often requires critical integration of the information obtained from clinical features, peripheral blood, bone marrow aspirate and biopsy findings. In this article we review the histopathology of bone marrow biopsy in PTCL within the context of the new WHO classification.

Original languageEnglish (US)
Pages (from-to)140-154
Number of pages15
JournalBritish Journal of Haematology
Volume127
Issue number2
DOIs
StatePublished - Oct 2004
Externally publishedYes

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Peripheral T-Cell Lymphoma
Bone Marrow
T-Cell Lymphoma
Biopsy
Large Granular Lymphocytic Leukemia
Lymphoproliferative Disorders
Lymphoma
Histology
Cell Proliferation
Pathology
T-Lymphocytes
Neoplasms

Keywords

  • Bone marrow
  • Immunohistochemistry
  • T-cell leukaemia
  • T-cell lymphoma

ASJC Scopus subject areas

  • Hematology

Cite this

Bone marrow histopathology in peripheral T-cell lymphomas. / Dogan, Ahmet; Morice, William G.

In: British Journal of Haematology, Vol. 127, No. 2, 10.2004, p. 140-154.

Research output: Contribution to journalArticle

Dogan, Ahmet ; Morice, William G. / Bone marrow histopathology in peripheral T-cell lymphomas. In: British Journal of Haematology. 2004 ; Vol. 127, No. 2. pp. 140-154.
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