Bone marrow histochemical studies of fibrogenic cytokines and their receptors in myelodysplastic syndrome with myelofibrosis and related disorders

Soo Young Yoon, Chin Yang Li, Ricardo V. Lloyd, Ayalew Tefferi

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Cellular and extracellular alterations of various fibrogenic cytokines have been described in a number of different chronic myeloid disorders that are associated with myelofibrosis. However, the available information related to both myelodysplastic syndrome with myelofibrosis (MDS-f) and bone marrow histochemical analysis is limited. In the current study, bone marrow immunohistochemical staining for platelet-derived growth factor, transforming growth factor (TGF)-β, basic fibroblast growth factor (bFGF), and their receptors was performed in 9 patients with MDS-f, 9 patients with essential thrombocythemia (ET), 8 patients with 5q- syndrome, and 5 healthy control subjects. In addition,TGF-β1 messenger RNA (mRNA) analysis was performed in 5 patients, each with MDS-f, myelofibrosis with myeloid metaplasia (MMM), polycythemia vera (PV), ET, and immune thrombocytopenic purpura, and in healthy control subjects. In general, protein and transcript expression patterns were similar to normal patterns and not significantly different amons the various disease groups. The only exception was a reduced concentration of bFGF-expressing stromal cells in patients with PV, ET, and MMM

Original languageEnglish (US)
Pages (from-to)337-342
Number of pages6
JournalInternational journal of hematology
Volume72
Issue number3
StatePublished - Dec 1 2000

Keywords

  • Chronic myeloid disorders
  • Fibrogenic cytokines
  • Myelodysplastic syndrome with myelofibrosis

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Bone marrow histochemical studies of fibrogenic cytokines and their receptors in myelodysplastic syndrome with myelofibrosis and related disorders'. Together they form a unique fingerprint.

  • Cite this