Bone marrow angiogenesis in patients achieving complete response after stem cell transplantation for multiple myeloma

Research output: Contribution to journalArticle

148 Scopus citations

Abstract

Although most of the initial studies in angiogenesis were done on solid tumors, there is now data suggesting the importance of angiogenesis in hematologic malignancies. We estimated bone marrow microvessel density before autologous stem cell transplantation and at the time of response in 13 patients with myeloma (seven complete and six partial responders) using an immunohistochemical stain for factor VIII-related antigen (von Willebrand factor). Baseline microvessel density was significantly different between bone marrow samples from patients with myeloma and morphologically normal, staging marrows from patients with limited stage Hodgkin's disease, mean (± s.d.) 294 (± 115)/mm2 vs 93 (± 26)/mm2, respectively, P = 0.001. After transplantation, microvessel density continued to be high in myeloma samples compared to samples from control patients with limited stage Hodgkin's disease, mean (± s.d.) 230 (± 68)/mm2, P = 0.003. There was no difference in microvessel density at the time of complete or partial response compared to values prior to transplantation. This report confirms that increased angiogenesis is found in myeloma bone marrow prior to transplantation, and suggests that increased angiogenesis persists even after complete response.

Original languageEnglish (US)
Pages (from-to)469-472
Number of pages4
JournalLeukemia
Volume13
Issue number3
DOIs
StatePublished - Jan 1 1999

Keywords

  • Angiogenesis
  • Complete response
  • Microvessel density
  • Multiple myeloma
  • Stem cell transplantation

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Bone marrow angiogenesis in patients achieving complete response after stem cell transplantation for multiple myeloma'. Together they form a unique fingerprint.

  • Cite this