Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis

Zengdi Zhang, Zan Huang, Brianna Ong, Chinmayi Sahu, Hu Zeng, Hai Bin Ruan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Hematopoiesis is dynamically regulated by metabolic cues in homeostatic and stressed conditions; however, the cellular and molecular mechanisms mediating the metabolic sensing and regulation remain largely obscure. Bone marrow adipose tissue remodels in various metabolic conditions and has been recently proposed as a niche for hematopoietic stem cells after irradiation. Here, we investigated the role of marrow adipose tissue-derived hematopoietic cytokine stem cell factor in unperturbed hematopoiesis by selectively ablating the Kitl gene from adipocytes and bone marrow stroma cells using Adipoq-Cre and Osx1-Cre, respectively. We found that both Adipoq-Kitl knockout (KO) and Osx1-Kitl KO mice diminished hematopoietic stem and progenitor cells and myeloid progenitors in the bone marrow and developed macrocytic anemia at the steady-state. The composition and differentiation of hematopoietic progenitor cells in the bone marrow dynamically responded to metabolic challenges including high fat diet, β3-adrenergic activation, thermoneutrality, and aging. However, such responses, particularly within the myeloid compartment, were largely impaired in Adipoq-Kitl KO mice. Our data demonstrate that marrow adipose tissue provides stem cell factor essentially for hematopoiesis both at the steady state and upon metabolic stresses.

Original languageEnglish (US)
Pages (from-to)1731-1743
Number of pages13
JournalHaematologica
Volume104
Issue number9
DOIs
StatePublished - Sep 1 2019

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Stem Cell Factor
Hematopoiesis
Hematopoietic Stem Cells
Adipose Tissue
Bone Marrow
Knockout Mice
Macrocytic Anemia
Physiological Stress
High Fat Diet
Adipocytes
Bone Marrow Cells
Adrenergic Agents
Cues
Cytokines
Genes

ASJC Scopus subject areas

  • Hematology

Cite this

Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis. / Zhang, Zengdi; Huang, Zan; Ong, Brianna; Sahu, Chinmayi; Zeng, Hu; Ruan, Hai Bin.

In: Haematologica, Vol. 104, No. 9, 01.09.2019, p. 1731-1743.

Research output: Contribution to journalArticle

Zhang, Zengdi ; Huang, Zan ; Ong, Brianna ; Sahu, Chinmayi ; Zeng, Hu ; Ruan, Hai Bin. / Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis. In: Haematologica. 2019 ; Vol. 104, No. 9. pp. 1731-1743.
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