Doença óssea no hipoparatiroidismo

Translated title of the contribution: Bone disease in hypoparathyroidism

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Hypoparathyroidism is a rare disorder that may be acquired or inherited. Postsurgical hypoparathyroidism is responsible for the majority of acquired hypoparathyroidism. Bone disease occurs in hypoparathyroidism due to markedly reduced bone remodeling due to the absence or low levels of parathyroid hormone. Chronically reduced bone turnover in patients with hypoparathyroidism typically leads to higher bone mass than in age- and sex-matched controls. Whether this increased bone density reduces fracture risk is less certain, because while increased bone mineralization may be associated with increased brittleness of bone, this does not appear to be the case in hypoparathyroidism. Treatment of hypoparathyroidism with recombi-nant parathyroid hormone may reduce bone mineral density but simultaneously strengthen the mechanical properties of bone.

Original languagePortuguese
Pages (from-to)545-552
Number of pages8
JournalArquivos Brasileiros de Endocrinologia e Metabologia
Volume58
Issue number5
DOIs
StatePublished - Jul 2014

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Keywords

  • Bone disease
  • Bone histomorphometry
  • Bone mineral density
  • Fractures
  • Hypoparathyroidism
  • Skeleton

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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