Body mass index is negatively associated with telomere length: A collaborative cross-sectional meta-analysis of 87 observational studies

TELOMAAS group

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10 Citations (Scopus)

Abstract

Background: Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the association between body mass index (BMI) and leukocyte telomere length (TL) might differ across the life span and between ethnicities and sexes. Objective: A collaborative cross-sectionalmeta-analysis of observational studies was conducted to investigate the associations between BMI and TL across the life span. Design: Eighty-seven distinct study samples were included in the meta-analysis capturing data from 146,114 individuals. Studyspecific age- and sex-adjusted regression coefficients were combined by using a random-effects model in which absolute [base pairs (bp)] and relative telomere to single-copy gene ratio (T/S ratio) TLs were regressed against BMI. Stratified analysis was performed by 3 age categories ("young": 18-60 y; "middle": 61-75 y; and "old": >75 y), sex, and ethnicity. Results: Each unit increase in BMI corresponded to a-3.99 bp (95% CI: -5.17, -2.81 bp) difference in TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a -7.67 bp (95% CI:-10.03,-5.31 bp) difference. Each unit increase in BMI corresponded to a -1.58 × 10-3 unit T/S ratio (0.16% decrease; 95% CI: -2.14 × 10-3, -1.01 × 10-3) difference in ageand sex-adjusted relative TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a -2.58 × 10-3 unit T/S ratio (0.26% decrease; 95% CI: -3.92 × 10-3, -1.25 × 10-3). The associations were predominantly for the white pooled population. No sex differences were observed. Conclusions: A higher BMI is associated with shorter telomeres, especially in younger individuals. The presently observed difference is not negligible. Meta-analyses of longitudinal studies evaluating change in body weight alongside change in TL arewarranted.

Original languageEnglish (US)
Pages (from-to)453-475
Number of pages23
JournalAmerican Journal of Clinical Nutrition
Volume108
Issue number3
DOIs
StatePublished - Sep 1 2018

Fingerprint

Telomere
Observational Studies
Meta-Analysis
Body Mass Index
Cross-Sectional Studies
Base Pairing
Young Adult
Obesity
Genes
Telomere Shortening
Body Weight Changes
Age of Onset
Sex Characteristics
Longitudinal Studies
Oxidative Stress
Leukocytes
Inflammation
Population

Keywords

  • BMI
  • Low-grade inflammation
  • Meta-analysis
  • Obesity
  • Observational studies
  • Telomere length

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

@article{2b0c25de6d9942f3ad1844257c9b4cb7,
title = "Body mass index is negatively associated with telomere length: A collaborative cross-sectional meta-analysis of 87 observational studies",
abstract = "Background: Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the association between body mass index (BMI) and leukocyte telomere length (TL) might differ across the life span and between ethnicities and sexes. Objective: A collaborative cross-sectionalmeta-analysis of observational studies was conducted to investigate the associations between BMI and TL across the life span. Design: Eighty-seven distinct study samples were included in the meta-analysis capturing data from 146,114 individuals. Studyspecific age- and sex-adjusted regression coefficients were combined by using a random-effects model in which absolute [base pairs (bp)] and relative telomere to single-copy gene ratio (T/S ratio) TLs were regressed against BMI. Stratified analysis was performed by 3 age categories ({"}young{"}: 18-60 y; {"}middle{"}: 61-75 y; and {"}old{"}: >75 y), sex, and ethnicity. Results: Each unit increase in BMI corresponded to a-3.99 bp (95{\%} CI: -5.17, -2.81 bp) difference in TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a -7.67 bp (95{\%} CI:-10.03,-5.31 bp) difference. Each unit increase in BMI corresponded to a -1.58 × 10-3 unit T/S ratio (0.16{\%} decrease; 95{\%} CI: -2.14 × 10-3, -1.01 × 10-3) difference in ageand sex-adjusted relative TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a -2.58 × 10-3 unit T/S ratio (0.26{\%} decrease; 95{\%} CI: -3.92 × 10-3, -1.25 × 10-3). The associations were predominantly for the white pooled population. No sex differences were observed. Conclusions: A higher BMI is associated with shorter telomeres, especially in younger individuals. The presently observed difference is not negligible. Meta-analyses of longitudinal studies evaluating change in body weight alongside change in TL arewarranted.",
keywords = "BMI, Low-grade inflammation, Meta-analysis, Obesity, Observational studies, Telomere length",
author = "{TELOMAAS group} and Marij Gielen and Hageman, {Geja J.} and Antoniou, {Evangelia E.} and Katarina Nordfjall and Massimo Mangino and Muthuswamy Balasubramanyam and {De Meyer}, Tim and Hendricks, {Audrey E.} and Giltay, {Erik J.} and Hunt, {Steven C.} and Nettleton, {Jennifer A.} and Salpea, {Klelia D.} and Diaz, {Vanessa A.} and Ramin Farzaneh-Far and Gil Atzmon and Harris, {Sarah E.} and Lifang Hou and David Gilley and Iiris Hovatta and Kark, {Jeremy D.} and Hisham Nassar and Kurz, {David J.} and Mather, {Karen A.} and Peter Willeit and Zheng, {Yun Ling} and Sofia Pavanello and Demerath, {Ellen W.} and Line Rode and Daniel Bunout and Andrew Steptoe and Boardman, {Lisa Allyn} and Amelia Marti and Belinda Needham and Wei Zheng and Rosalind Ramsey-Goldman and Pellatt, {Andrew J.} and Jaakko Kaprio and Hofmann, {Jonathan N.} and Christian Gieger and Giuseppe Paolisso and Hjelmborg, {Jacob B.H.} and Lisa Mirabello and Teresa Seeman and Jason Wong and {Van Der Harst}, Pim and Linda Broer and Florian Kronenberg and Barbara Kollerits and Timo Strandberg and Eisenberg, {Dan T.A.}",
year = "2018",
month = "9",
day = "1",
doi = "10.1093/ajcn/nqy107",
language = "English (US)",
volume = "108",
pages = "453--475",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "3",

}

TY - JOUR

T1 - Body mass index is negatively associated with telomere length

T2 - A collaborative cross-sectional meta-analysis of 87 observational studies

AU - TELOMAAS group

AU - Gielen, Marij

AU - Hageman, Geja J.

AU - Antoniou, Evangelia E.

AU - Nordfjall, Katarina

AU - Mangino, Massimo

AU - Balasubramanyam, Muthuswamy

AU - De Meyer, Tim

AU - Hendricks, Audrey E.

AU - Giltay, Erik J.

AU - Hunt, Steven C.

AU - Nettleton, Jennifer A.

AU - Salpea, Klelia D.

AU - Diaz, Vanessa A.

AU - Farzaneh-Far, Ramin

AU - Atzmon, Gil

AU - Harris, Sarah E.

AU - Hou, Lifang

AU - Gilley, David

AU - Hovatta, Iiris

AU - Kark, Jeremy D.

AU - Nassar, Hisham

AU - Kurz, David J.

AU - Mather, Karen A.

AU - Willeit, Peter

AU - Zheng, Yun Ling

AU - Pavanello, Sofia

AU - Demerath, Ellen W.

AU - Rode, Line

AU - Bunout, Daniel

AU - Steptoe, Andrew

AU - Boardman, Lisa Allyn

AU - Marti, Amelia

AU - Needham, Belinda

AU - Zheng, Wei

AU - Ramsey-Goldman, Rosalind

AU - Pellatt, Andrew J.

AU - Kaprio, Jaakko

AU - Hofmann, Jonathan N.

AU - Gieger, Christian

AU - Paolisso, Giuseppe

AU - Hjelmborg, Jacob B.H.

AU - Mirabello, Lisa

AU - Seeman, Teresa

AU - Wong, Jason

AU - Van Der Harst, Pim

AU - Broer, Linda

AU - Kronenberg, Florian

AU - Kollerits, Barbara

AU - Strandberg, Timo

AU - Eisenberg, Dan T.A.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Background: Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the association between body mass index (BMI) and leukocyte telomere length (TL) might differ across the life span and between ethnicities and sexes. Objective: A collaborative cross-sectionalmeta-analysis of observational studies was conducted to investigate the associations between BMI and TL across the life span. Design: Eighty-seven distinct study samples were included in the meta-analysis capturing data from 146,114 individuals. Studyspecific age- and sex-adjusted regression coefficients were combined by using a random-effects model in which absolute [base pairs (bp)] and relative telomere to single-copy gene ratio (T/S ratio) TLs were regressed against BMI. Stratified analysis was performed by 3 age categories ("young": 18-60 y; "middle": 61-75 y; and "old": >75 y), sex, and ethnicity. Results: Each unit increase in BMI corresponded to a-3.99 bp (95% CI: -5.17, -2.81 bp) difference in TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a -7.67 bp (95% CI:-10.03,-5.31 bp) difference. Each unit increase in BMI corresponded to a -1.58 × 10-3 unit T/S ratio (0.16% decrease; 95% CI: -2.14 × 10-3, -1.01 × 10-3) difference in ageand sex-adjusted relative TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a -2.58 × 10-3 unit T/S ratio (0.26% decrease; 95% CI: -3.92 × 10-3, -1.25 × 10-3). The associations were predominantly for the white pooled population. No sex differences were observed. Conclusions: A higher BMI is associated with shorter telomeres, especially in younger individuals. The presently observed difference is not negligible. Meta-analyses of longitudinal studies evaluating change in body weight alongside change in TL arewarranted.

AB - Background: Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the association between body mass index (BMI) and leukocyte telomere length (TL) might differ across the life span and between ethnicities and sexes. Objective: A collaborative cross-sectionalmeta-analysis of observational studies was conducted to investigate the associations between BMI and TL across the life span. Design: Eighty-seven distinct study samples were included in the meta-analysis capturing data from 146,114 individuals. Studyspecific age- and sex-adjusted regression coefficients were combined by using a random-effects model in which absolute [base pairs (bp)] and relative telomere to single-copy gene ratio (T/S ratio) TLs were regressed against BMI. Stratified analysis was performed by 3 age categories ("young": 18-60 y; "middle": 61-75 y; and "old": >75 y), sex, and ethnicity. Results: Each unit increase in BMI corresponded to a-3.99 bp (95% CI: -5.17, -2.81 bp) difference in TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a -7.67 bp (95% CI:-10.03,-5.31 bp) difference. Each unit increase in BMI corresponded to a -1.58 × 10-3 unit T/S ratio (0.16% decrease; 95% CI: -2.14 × 10-3, -1.01 × 10-3) difference in ageand sex-adjusted relative TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a -2.58 × 10-3 unit T/S ratio (0.26% decrease; 95% CI: -3.92 × 10-3, -1.25 × 10-3). The associations were predominantly for the white pooled population. No sex differences were observed. Conclusions: A higher BMI is associated with shorter telomeres, especially in younger individuals. The presently observed difference is not negligible. Meta-analyses of longitudinal studies evaluating change in body weight alongside change in TL arewarranted.

KW - BMI

KW - Low-grade inflammation

KW - Meta-analysis

KW - Obesity

KW - Observational studies

KW - Telomere length

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U2 - 10.1093/ajcn/nqy107

DO - 10.1093/ajcn/nqy107

M3 - Article

C2 - 30535086

AN - SCOPUS:85054190686

VL - 108

SP - 453

EP - 475

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 3

ER -