Body Mass Index Effect on Differing Responses to Psychological Stress in Blood Glucose Dynamics in Patients With Type 1 Diabetes

Basak Ozaslan, Stephen D. Patek, Jesse H. Grabman, Jaclyn A. Shepard, Eyal Dassau, Marc D. Breton, Yogish C Kudva, Sue A. Brown, Ananda Basu, Jordan E. Pinsker, Francis J. Doyle, Linda Gonder-Frederick

Research output: Contribution to journalArticle

Abstract

Objective: The objective was to investigate the relationship of body mass index (BMI) to differing glycemic responses to psychological stress in patients with type 1 diabetes. Methods: Continuous blood glucose monitor (CGM) data were collected for 1 week from a total of 37 patients with BMI ranging from 21.5-39.4 kg/m2 (mean = 28.2 ± 4.9). Patients reported daily stress levels (5-point Likert-type scale, 0 = none, 4 = extreme), physical activity, carbohydrate intake, insulin boluses and basal rates. Daily reported carbohydrates, total insulin bolus, and average blood glucose (BG from CGM) were compared among patients based on their BMI levels on days with different stress levels. In addition, daily averages of a model-based “effectiveness index” (quantifying the combined impact of insulin and carbohydrate on glucose levels) were defined and compared across stress levels to capture meal and insulin independent glycemic changes. Results: Analyses showed that patient BMI likely moderated stress related glycemic changes. Linear mixed effect model results were significant for the stress-BMI interaction on both behavioral and behavior-independent glycemic changes. Across participants, under stress, an increase was observed in daily carbohydrate intake and effectiveness index at higher BMI. There was no significant interactive effect on daily insulin or average BG. Conclusion: Findings suggest that (1) stress has both behavioral and nonbehavioral glycemic effects on T1D patients and (2) the direction and magnitude of these effects are potentially influenced by level of stress and patient BMI. Possibly responsible for these observed effects are T1D/BMI related alterations in endocrine response.

Original languageEnglish (US)
JournalJournal of diabetes science and technology
DOIs
StateAccepted/In press - Feb 1 2018

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Medical problems
Type 1 Diabetes Mellitus
Psychological Stress
Glucose
Blood Glucose
Body Mass Index
Insulin
Blood
Carbohydrates
Meals
Exercise

Keywords

  • body mass index
  • effectiveness index
  • glycemic variability
  • stress
  • type 1 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Bioengineering
  • Biomedical Engineering

Cite this

Body Mass Index Effect on Differing Responses to Psychological Stress in Blood Glucose Dynamics in Patients With Type 1 Diabetes. / Ozaslan, Basak; Patek, Stephen D.; Grabman, Jesse H.; Shepard, Jaclyn A.; Dassau, Eyal; Breton, Marc D.; Kudva, Yogish C; Brown, Sue A.; Basu, Ananda; Pinsker, Jordan E.; Doyle, Francis J.; Gonder-Frederick, Linda.

In: Journal of diabetes science and technology, 01.02.2018.

Research output: Contribution to journalArticle

Ozaslan, B, Patek, SD, Grabman, JH, Shepard, JA, Dassau, E, Breton, MD, Kudva, YC, Brown, SA, Basu, A, Pinsker, JE, Doyle, FJ & Gonder-Frederick, L 2018, 'Body Mass Index Effect on Differing Responses to Psychological Stress in Blood Glucose Dynamics in Patients With Type 1 Diabetes', Journal of diabetes science and technology. https://doi.org/10.1177/1932296818758103
Ozaslan, Basak ; Patek, Stephen D. ; Grabman, Jesse H. ; Shepard, Jaclyn A. ; Dassau, Eyal ; Breton, Marc D. ; Kudva, Yogish C ; Brown, Sue A. ; Basu, Ananda ; Pinsker, Jordan E. ; Doyle, Francis J. ; Gonder-Frederick, Linda. / Body Mass Index Effect on Differing Responses to Psychological Stress in Blood Glucose Dynamics in Patients With Type 1 Diabetes. In: Journal of diabetes science and technology. 2018.
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