TY - JOUR
T1 - Body mass index and mortality in patients with idiopathic pulmonary fibrosis
AU - Alakhras, Mazen
AU - Decker, Paul A.
AU - Nadrous, Hassan F.
AU - Collazo-Clavell, Maria
AU - Ryu, Jay H.
N1 - Funding Information:
This research was supported by the Mayo Institutional funds and the Robert N. Brewer Family Foundation.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2007/5
Y1 - 2007/5
N2 - Background: To examine the relationship between body mass index (BMI) and mortality in patients with idiopathic pulmonary fibrosis (IPF). Methods: We studied a cohort of patients with IPF who were seen at the Mayo Clinic Rochester from 1994 through 1996. These patients met the current consensus definition of IPF. We excluded patients who had received prior treatment for IPF, had no follow-up data, or had no pulmonary function results available at the index visit. Results: Of the 197 patients fulfilling the inclusion criteria, the mean (± SD) age was 71.4 ± 8.9 years, 137 patients (70%) were men, and the mean BMI was 28.2 ± 4.6. These patients were categorized by BMI into the following three groups: < 25; 25 to 30; and ≥ 30. There were 46 patients (23%) with a BMI of < 25 who had a median survival lime of 3.6 years (1-year survival rate, 76% [95% confidence interval (CI), 65 to 90%]; 3-year survival rate, 54% [95% CI, 41 to 70%]). The second group consisted of 85 patients (43%) with a BMI between 25 and 30 who had a median survival time of 3.8 years (1-year survival rate, 84% [95% CI, 76 to 92%]; 3-year survival rate, 58% [95% CI, 48 to 70%]). The final group consisted of 66 patients (34%) with a BMI of ≥ 30 and who had a median survival time of 5.8 years (1-year survival rate, 91% [95% CI, 84 to 98%]; 3-year survival rate, 69% [95% CI, 58 to 81%]). Using a proportional hazards regression model, survival was significantly associated with BMI (hazard ratio, 0.93 for each 1-U increase in BMI; 95% CI, 0.89 to 0.97; p = 0.002) with increased BMI being associated with better survival. Conclusion: Higher BMI was associated with better survival in patients with IPF.
AB - Background: To examine the relationship between body mass index (BMI) and mortality in patients with idiopathic pulmonary fibrosis (IPF). Methods: We studied a cohort of patients with IPF who were seen at the Mayo Clinic Rochester from 1994 through 1996. These patients met the current consensus definition of IPF. We excluded patients who had received prior treatment for IPF, had no follow-up data, or had no pulmonary function results available at the index visit. Results: Of the 197 patients fulfilling the inclusion criteria, the mean (± SD) age was 71.4 ± 8.9 years, 137 patients (70%) were men, and the mean BMI was 28.2 ± 4.6. These patients were categorized by BMI into the following three groups: < 25; 25 to 30; and ≥ 30. There were 46 patients (23%) with a BMI of < 25 who had a median survival lime of 3.6 years (1-year survival rate, 76% [95% confidence interval (CI), 65 to 90%]; 3-year survival rate, 54% [95% CI, 41 to 70%]). The second group consisted of 85 patients (43%) with a BMI between 25 and 30 who had a median survival time of 3.8 years (1-year survival rate, 84% [95% CI, 76 to 92%]; 3-year survival rate, 58% [95% CI, 48 to 70%]). The final group consisted of 66 patients (34%) with a BMI of ≥ 30 and who had a median survival time of 5.8 years (1-year survival rate, 91% [95% CI, 84 to 98%]; 3-year survival rate, 69% [95% CI, 58 to 81%]). Using a proportional hazards regression model, survival was significantly associated with BMI (hazard ratio, 0.93 for each 1-U increase in BMI; 95% CI, 0.89 to 0.97; p = 0.002) with increased BMI being associated with better survival. Conclusion: Higher BMI was associated with better survival in patients with IPF.
KW - Body mass index
KW - Interstitial lung disease
KW - Mortality
KW - Nutrition
KW - Prognosis
KW - Pulmonary fibrosis
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U2 - 10.1378/chest.06-2784
DO - 10.1378/chest.06-2784
M3 - Article
C2 - 17400656
AN - SCOPUS:34248547178
SN - 0012-3692
VL - 131
SP - 1448
EP - 1453
JO - Chest
JF - Chest
IS - 5
ER -