Body-composition changes in patients who gain weight while receiving megestrol acetate

Research output: Contribution to journalArticle

182 Citations (Scopus)

Abstract

Purpose: Randomized placebo-controlled clinical trials have now established that megestrol acetate causes appetite stimulation and weight gain in patients with anorexia and/or cachexia. There is a paucity of available data to delineate the substance of this increased weight. Patients and Methods: Using dual-energy x-ray absorptiometry and fritiated body water methodologies, we performed body-composition measurements in 12 patients with advanced cancer before the institution of oral megestrol acetate (800 mg/d) and at subsequent 2-month intervals. Results; Seven of the 12 patients gained weight (2.1 to 16.5 kg) and had repeat body-composition measurements performed at the time of maximum weight gain. The vast majority of the gained weight was clearly from an increase in adipose tissue, while there was a suggestion that an increase in body fluid was responsible for a minority of the weight gain. Conclusion: Megestrol acetate-induced weight gain is primarily the result of an increase in body mass.

Original languageEnglish (US)
Pages (from-to)152-154
Number of pages3
JournalJournal of Clinical Oncology
Volume11
Issue number1
StatePublished - 1993

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Megestrol Acetate
Body Composition
Weight Gain
Weights and Measures
Cachexia
Body Water
Anorexia
Body Fluids
Appetite
Adipose Tissue
Randomized Controlled Trials
Placebos
X-Rays
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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Body-composition changes in patients who gain weight while receiving megestrol acetate. / Loprinzi, Charles Lawrence; Schaid, Daniel J; Dose, A. M.; Burnham, N. L.; Jensen, Michael Dennis.

In: Journal of Clinical Oncology, Vol. 11, No. 1, 1993, p. 152-154.

Research output: Contribution to journalArticle

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