Bloodstream infections in patients with transcatheter aortic valve replacement

Khawaja M. Talha; Jack W. McHugh; Daniel C. DeSimone; Karen M. Fischer; Mackram F. Eleid; Jennifer St. Sauver; M. Rizwan Sohail; Larry M. Baddour

doi:10.1016/j.diagmicrobio.2021.115456

Bloodstream infections in patients with transcatheter aortic valve replacement

Khawaja M. Talha, Jack W. McHugh, Daniel C. DeSimone, Karen M. Fischer, Mackram F. Eleid, Jennifer St. Sauver, M. Rizwan Sohail, Larry M. Baddour

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To evaluate incidence and risk factors of bloodstream infections (BSI) in patients with transcatheter aortic valve replacement (TAVR). Methods: We conducted a population-based study in southeastern Minnesota using the expanded Rochester Epidemiology Project (e-REP) for all adult (≥18 years) patients who underwent TAVR from January 1, 2010 to December 31, 2018. Results: The incidence of BSI following TAVR was 1300 episodes/100,000 persons per annum. The median time to BSI following TAVR was 610 days and 84% were community-acquired. Forty percent of BSI cases developed infective endocarditis. Viridans group streptococci (VGS) were the most common pathogens and 80% of patients with VGS BSI had IE. Conclusions: The high incidence of BSI among TAVR patients is alarming and is likely due to advanced age and comorbid conditions. Because 40% of BSI patients also developed IE, further investigation of modifiable risk factors associated with BSI is warranted.

Original language	English (US)
Article number	115456
Journal	Diagnostic Microbiology and Infectious Disease
Volume	101
Issue number	3
DOIs	https://doi.org/10.1016/j.diagmicrobio.2021.115456
State	Published - Nov 2021

Keywords

bloodstream infections
incidence
infective endocarditis
population-based
transcatheter aortic valve replacement

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1016/j.diagmicrobio.2021.115456

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title = "Bloodstream infections in patients with transcatheter aortic valve replacement",

abstract = "Objective: To evaluate incidence and risk factors of bloodstream infections (BSI) in patients with transcatheter aortic valve replacement (TAVR). Methods: We conducted a population-based study in southeastern Minnesota using the expanded Rochester Epidemiology Project (e-REP) for all adult (≥18 years) patients who underwent TAVR from January 1, 2010 to December 31, 2018. Results: The incidence of BSI following TAVR was 1300 episodes/100,000 persons per annum. The median time to BSI following TAVR was 610 days and 84% were community-acquired. Forty percent of BSI cases developed infective endocarditis. Viridans group streptococci (VGS) were the most common pathogens and 80% of patients with VGS BSI had IE. Conclusions: The high incidence of BSI among TAVR patients is alarming and is likely due to advanced age and comorbid conditions. Because 40% of BSI patients also developed IE, further investigation of modifiable risk factors associated with BSI is warranted.",

keywords = "bloodstream infections, incidence, infective endocarditis, population-based, transcatheter aortic valve replacement",

author = "Talha, {Khawaja M.} and McHugh, {Jack W.} and DeSimone, {Daniel C.} and Fischer, {Karen M.} and Eleid, {Mackram F.} and {St. Sauver}, Jennifer and Sohail, {M. Rizwan} and Baddour, {Larry M.}",

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year = "2021",

month = nov,

doi = "10.1016/j.diagmicrobio.2021.115456",

language = "English (US)",

volume = "101",

journal = "Diagnostic Microbiology and Infectious Disease",

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AU - Talha, Khawaja M.

AU - McHugh, Jack W.

AU - DeSimone, Daniel C.

AU - Fischer, Karen M.

AU - Eleid, Mackram F.

AU - St. Sauver, Jennifer

AU - Sohail, M. Rizwan

AU - Baddour, Larry M.

PY - 2021/11

Y1 - 2021/11

N2 - Objective: To evaluate incidence and risk factors of bloodstream infections (BSI) in patients with transcatheter aortic valve replacement (TAVR). Methods: We conducted a population-based study in southeastern Minnesota using the expanded Rochester Epidemiology Project (e-REP) for all adult (≥18 years) patients who underwent TAVR from January 1, 2010 to December 31, 2018. Results: The incidence of BSI following TAVR was 1300 episodes/100,000 persons per annum. The median time to BSI following TAVR was 610 days and 84% were community-acquired. Forty percent of BSI cases developed infective endocarditis. Viridans group streptococci (VGS) were the most common pathogens and 80% of patients with VGS BSI had IE. Conclusions: The high incidence of BSI among TAVR patients is alarming and is likely due to advanced age and comorbid conditions. Because 40% of BSI patients also developed IE, further investigation of modifiable risk factors associated with BSI is warranted.

AB - Objective: To evaluate incidence and risk factors of bloodstream infections (BSI) in patients with transcatheter aortic valve replacement (TAVR). Methods: We conducted a population-based study in southeastern Minnesota using the expanded Rochester Epidemiology Project (e-REP) for all adult (≥18 years) patients who underwent TAVR from January 1, 2010 to December 31, 2018. Results: The incidence of BSI following TAVR was 1300 episodes/100,000 persons per annum. The median time to BSI following TAVR was 610 days and 84% were community-acquired. Forty percent of BSI cases developed infective endocarditis. Viridans group streptococci (VGS) were the most common pathogens and 80% of patients with VGS BSI had IE. Conclusions: The high incidence of BSI among TAVR patients is alarming and is likely due to advanced age and comorbid conditions. Because 40% of BSI patients also developed IE, further investigation of modifiable risk factors associated with BSI is warranted.

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KW - transcatheter aortic valve replacement

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Bloodstream infections in patients with transcatheter aortic valve replacement

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