Blood transfusion history and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis

James R Cerhan, Eleanor Kane, Claire M. Vajdic, Martha S. Linet, Alain Monnereau, Leslie Bernstein, Silvia de Sanjose, Brian C.H. Chiu, John J. Spinelli, Luigino Dal Maso, Yawei Zhang, Beth R. Larrabee, Wendy Cozen, Alexandra G. Smith, Jacqueline Clavel, Diego Serraino, Tongzhang Zheng, Elizabeth A. Holly, Dennis D. Weisenberger, Susan L SlagerPaige M. Bracci

Research output: Contribution to journalArticle

Abstract

Purpose: To conduct a pooled analysis assessing the association of blood transfusion with risk of non-Hodgkin lymphoma (NHL). Methods: We used harmonized data from 13 case–control studies (10,805 cases, 14,026 controls) in the InterLymph Consortium. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression, adjusted for study design variables. Results: Among non-Hispanic whites (NHW), history of any transfusion was inversely associated with NHL risk for men (OR 0.74; 95% CI 0.65–0.83) but not women (OR 0.92; 95% CI 0.83–1.03), pheterogeneity = 0.014. Transfusion history was not associated with risk in other racial/ethnic groups. There was no trend with the number of transfusions, time since first transfusion, age at first transfusion, or decade of first transfusion, and further adjustment for socioeconomic status, body mass index, smoking, alcohol use, and HCV seropositivity did not alter the results. Associations for NHW men were stronger in hospital-based (OR 0.56; 95% CI 0.45–0.70) but still apparent in population-based (OR 0.84; 95% CI 0.72–0.98) studies. Conclusions: In the setting of a literature reporting mainly null and some positive associations, and the lack of a clear methodologic explanation for our inverse association restricted to NHW men, the current body of evidence suggests that there is no association of blood transfusion with risk of NHL.

Original languageEnglish (US)
JournalCancer Causes and Control
DOIs
StatePublished - Jan 1 2019

Fingerprint

Blood Transfusion
Non-Hodgkin's Lymphoma
History
Odds Ratio
Confidence Intervals
Ethnic Groups
Social Class
Body Mass Index
Logistic Models
Smoking
Alcohols
Population

Keywords

  • Epidemiology
  • Etiology
  • Lymphoma
  • Pooled analysis
  • Transfusion

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Blood transfusion history and risk of non-Hodgkin lymphoma : an InterLymph pooled analysis. / Cerhan, James R; Kane, Eleanor; Vajdic, Claire M.; Linet, Martha S.; Monnereau, Alain; Bernstein, Leslie; de Sanjose, Silvia; Chiu, Brian C.H.; Spinelli, John J.; Maso, Luigino Dal; Zhang, Yawei; Larrabee, Beth R.; Cozen, Wendy; Smith, Alexandra G.; Clavel, Jacqueline; Serraino, Diego; Zheng, Tongzhang; Holly, Elizabeth A.; Weisenberger, Dennis D.; Slager, Susan L; Bracci, Paige M.

In: Cancer Causes and Control, 01.01.2019.

Research output: Contribution to journalArticle

Cerhan, JR, Kane, E, Vajdic, CM, Linet, MS, Monnereau, A, Bernstein, L, de Sanjose, S, Chiu, BCH, Spinelli, JJ, Maso, LD, Zhang, Y, Larrabee, BR, Cozen, W, Smith, AG, Clavel, J, Serraino, D, Zheng, T, Holly, EA, Weisenberger, DD, Slager, SL & Bracci, PM 2019, 'Blood transfusion history and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis', Cancer Causes and Control. https://doi.org/10.1007/s10552-019-01188-w
Cerhan, James R ; Kane, Eleanor ; Vajdic, Claire M. ; Linet, Martha S. ; Monnereau, Alain ; Bernstein, Leslie ; de Sanjose, Silvia ; Chiu, Brian C.H. ; Spinelli, John J. ; Maso, Luigino Dal ; Zhang, Yawei ; Larrabee, Beth R. ; Cozen, Wendy ; Smith, Alexandra G. ; Clavel, Jacqueline ; Serraino, Diego ; Zheng, Tongzhang ; Holly, Elizabeth A. ; Weisenberger, Dennis D. ; Slager, Susan L ; Bracci, Paige M. / Blood transfusion history and risk of non-Hodgkin lymphoma : an InterLymph pooled analysis. In: Cancer Causes and Control. 2019.
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abstract = "Purpose: To conduct a pooled analysis assessing the association of blood transfusion with risk of non-Hodgkin lymphoma (NHL). Methods: We used harmonized data from 13 case–control studies (10,805 cases, 14,026 controls) in the InterLymph Consortium. Odds ratios (OR) and 95{\%} confidence intervals (CI) were calculated using unconditional logistic regression, adjusted for study design variables. Results: Among non-Hispanic whites (NHW), history of any transfusion was inversely associated with NHL risk for men (OR 0.74; 95{\%} CI 0.65–0.83) but not women (OR 0.92; 95{\%} CI 0.83–1.03), pheterogeneity = 0.014. Transfusion history was not associated with risk in other racial/ethnic groups. There was no trend with the number of transfusions, time since first transfusion, age at first transfusion, or decade of first transfusion, and further adjustment for socioeconomic status, body mass index, smoking, alcohol use, and HCV seropositivity did not alter the results. Associations for NHW men were stronger in hospital-based (OR 0.56; 95{\%} CI 0.45–0.70) but still apparent in population-based (OR 0.84; 95{\%} CI 0.72–0.98) studies. Conclusions: In the setting of a literature reporting mainly null and some positive associations, and the lack of a clear methodologic explanation for our inverse association restricted to NHW men, the current body of evidence suggests that there is no association of blood transfusion with risk of NHL.",
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T1 - Blood transfusion history and risk of non-Hodgkin lymphoma

T2 - an InterLymph pooled analysis

AU - Cerhan, James R

AU - Kane, Eleanor

AU - Vajdic, Claire M.

AU - Linet, Martha S.

AU - Monnereau, Alain

AU - Bernstein, Leslie

AU - de Sanjose, Silvia

AU - Chiu, Brian C.H.

AU - Spinelli, John J.

AU - Maso, Luigino Dal

AU - Zhang, Yawei

AU - Larrabee, Beth R.

AU - Cozen, Wendy

AU - Smith, Alexandra G.

AU - Clavel, Jacqueline

AU - Serraino, Diego

AU - Zheng, Tongzhang

AU - Holly, Elizabeth A.

AU - Weisenberger, Dennis D.

AU - Slager, Susan L

AU - Bracci, Paige M.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: To conduct a pooled analysis assessing the association of blood transfusion with risk of non-Hodgkin lymphoma (NHL). Methods: We used harmonized data from 13 case–control studies (10,805 cases, 14,026 controls) in the InterLymph Consortium. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression, adjusted for study design variables. Results: Among non-Hispanic whites (NHW), history of any transfusion was inversely associated with NHL risk for men (OR 0.74; 95% CI 0.65–0.83) but not women (OR 0.92; 95% CI 0.83–1.03), pheterogeneity = 0.014. Transfusion history was not associated with risk in other racial/ethnic groups. There was no trend with the number of transfusions, time since first transfusion, age at first transfusion, or decade of first transfusion, and further adjustment for socioeconomic status, body mass index, smoking, alcohol use, and HCV seropositivity did not alter the results. Associations for NHW men were stronger in hospital-based (OR 0.56; 95% CI 0.45–0.70) but still apparent in population-based (OR 0.84; 95% CI 0.72–0.98) studies. Conclusions: In the setting of a literature reporting mainly null and some positive associations, and the lack of a clear methodologic explanation for our inverse association restricted to NHW men, the current body of evidence suggests that there is no association of blood transfusion with risk of NHL.

AB - Purpose: To conduct a pooled analysis assessing the association of blood transfusion with risk of non-Hodgkin lymphoma (NHL). Methods: We used harmonized data from 13 case–control studies (10,805 cases, 14,026 controls) in the InterLymph Consortium. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression, adjusted for study design variables. Results: Among non-Hispanic whites (NHW), history of any transfusion was inversely associated with NHL risk for men (OR 0.74; 95% CI 0.65–0.83) but not women (OR 0.92; 95% CI 0.83–1.03), pheterogeneity = 0.014. Transfusion history was not associated with risk in other racial/ethnic groups. There was no trend with the number of transfusions, time since first transfusion, age at first transfusion, or decade of first transfusion, and further adjustment for socioeconomic status, body mass index, smoking, alcohol use, and HCV seropositivity did not alter the results. Associations for NHW men were stronger in hospital-based (OR 0.56; 95% CI 0.45–0.70) but still apparent in population-based (OR 0.84; 95% CI 0.72–0.98) studies. Conclusions: In the setting of a literature reporting mainly null and some positive associations, and the lack of a clear methodologic explanation for our inverse association restricted to NHW men, the current body of evidence suggests that there is no association of blood transfusion with risk of NHL.

KW - Epidemiology

KW - Etiology

KW - Lymphoma

KW - Pooled analysis

KW - Transfusion

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