Abstract
Purpose: To conduct a pooled analysis assessing the association of blood transfusion with risk of non-Hodgkin lymphoma (NHL). Methods: We used harmonized data from 13 case–control studies (10,805 cases, 14,026 controls) in the InterLymph Consortium. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression, adjusted for study design variables. Results: Among non-Hispanic whites (NHW), history of any transfusion was inversely associated with NHL risk for men (OR 0.74; 95% CI 0.65–0.83) but not women (OR 0.92; 95% CI 0.83–1.03), pheterogeneity = 0.014. Transfusion history was not associated with risk in other racial/ethnic groups. There was no trend with the number of transfusions, time since first transfusion, age at first transfusion, or decade of first transfusion, and further adjustment for socioeconomic status, body mass index, smoking, alcohol use, and HCV seropositivity did not alter the results. Associations for NHW men were stronger in hospital-based (OR 0.56; 95% CI 0.45–0.70) but still apparent in population-based (OR 0.84; 95% CI 0.72–0.98) studies. Conclusions: In the setting of a literature reporting mainly null and some positive associations, and the lack of a clear methodologic explanation for our inverse association restricted to NHW men, the current body of evidence suggests that there is no association of blood transfusion with risk of NHL.
| Original language | English (US) |
|---|---|
| Journal | Cancer Causes and Control |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- Epidemiology
- Etiology
- Lymphoma
- Pooled analysis
- Transfusion
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Blood transfusion history and risk of non-Hodgkin lymphoma : an InterLymph pooled analysis. / Cerhan, James R; Kane, Eleanor; Vajdic, Claire M.; Linet, Martha S.; Monnereau, Alain; Bernstein, Leslie; de Sanjose, Silvia; Chiu, Brian C.H.; Spinelli, John J.; Maso, Luigino Dal; Zhang, Yawei; Larrabee, Beth R.; Cozen, Wendy; Smith, Alexandra G.; Clavel, Jacqueline; Serraino, Diego; Zheng, Tongzhang; Holly, Elizabeth A.; Weisenberger, Dennis D.; Slager, Susan L; Bracci, Paige M.
In: Cancer Causes and Control, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Blood transfusion history and risk of non-Hodgkin lymphoma
T2 - an InterLymph pooled analysis
AU - Cerhan, James R
AU - Kane, Eleanor
AU - Vajdic, Claire M.
AU - Linet, Martha S.
AU - Monnereau, Alain
AU - Bernstein, Leslie
AU - de Sanjose, Silvia
AU - Chiu, Brian C.H.
AU - Spinelli, John J.
AU - Maso, Luigino Dal
AU - Zhang, Yawei
AU - Larrabee, Beth R.
AU - Cozen, Wendy
AU - Smith, Alexandra G.
AU - Clavel, Jacqueline
AU - Serraino, Diego
AU - Zheng, Tongzhang
AU - Holly, Elizabeth A.
AU - Weisenberger, Dennis D.
AU - Slager, Susan L
AU - Bracci, Paige M.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Purpose: To conduct a pooled analysis assessing the association of blood transfusion with risk of non-Hodgkin lymphoma (NHL). Methods: We used harmonized data from 13 case–control studies (10,805 cases, 14,026 controls) in the InterLymph Consortium. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression, adjusted for study design variables. Results: Among non-Hispanic whites (NHW), history of any transfusion was inversely associated with NHL risk for men (OR 0.74; 95% CI 0.65–0.83) but not women (OR 0.92; 95% CI 0.83–1.03), pheterogeneity = 0.014. Transfusion history was not associated with risk in other racial/ethnic groups. There was no trend with the number of transfusions, time since first transfusion, age at first transfusion, or decade of first transfusion, and further adjustment for socioeconomic status, body mass index, smoking, alcohol use, and HCV seropositivity did not alter the results. Associations for NHW men were stronger in hospital-based (OR 0.56; 95% CI 0.45–0.70) but still apparent in population-based (OR 0.84; 95% CI 0.72–0.98) studies. Conclusions: In the setting of a literature reporting mainly null and some positive associations, and the lack of a clear methodologic explanation for our inverse association restricted to NHW men, the current body of evidence suggests that there is no association of blood transfusion with risk of NHL.
AB - Purpose: To conduct a pooled analysis assessing the association of blood transfusion with risk of non-Hodgkin lymphoma (NHL). Methods: We used harmonized data from 13 case–control studies (10,805 cases, 14,026 controls) in the InterLymph Consortium. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression, adjusted for study design variables. Results: Among non-Hispanic whites (NHW), history of any transfusion was inversely associated with NHL risk for men (OR 0.74; 95% CI 0.65–0.83) but not women (OR 0.92; 95% CI 0.83–1.03), pheterogeneity = 0.014. Transfusion history was not associated with risk in other racial/ethnic groups. There was no trend with the number of transfusions, time since first transfusion, age at first transfusion, or decade of first transfusion, and further adjustment for socioeconomic status, body mass index, smoking, alcohol use, and HCV seropositivity did not alter the results. Associations for NHW men were stronger in hospital-based (OR 0.56; 95% CI 0.45–0.70) but still apparent in population-based (OR 0.84; 95% CI 0.72–0.98) studies. Conclusions: In the setting of a literature reporting mainly null and some positive associations, and the lack of a clear methodologic explanation for our inverse association restricted to NHW men, the current body of evidence suggests that there is no association of blood transfusion with risk of NHL.
KW - Epidemiology
KW - Etiology
KW - Lymphoma
KW - Pooled analysis
KW - Transfusion
UR - http://www.scopus.com/inward/record.url?scp=85067073783&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067073783&partnerID=8YFLogxK
U2 - 10.1007/s10552-019-01188-w
DO - 10.1007/s10552-019-01188-w
M3 - Article
C2 - 31165419
AN - SCOPUS:85067073783
JO - Cancer Causes and Control
JF - Cancer Causes and Control
SN - 0957-5243
ER -