Blood transfusion history and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis

James R. Cerhan; Eleanor Kane; Claire M. Vajdic; Martha S. Linet; Alain Monnereau; Leslie Bernstein; Silvia de Sanjose; Brian C.H. Chiu; John J. Spinelli; Luigino Dal Maso; Yawei Zhang; Beth R. Larrabee; Wendy Cozen; Alexandra G. Smith; Jacqueline Clavel; Diego Serraino; Tongzhang Zheng; Elizabeth A. Holly; Dennis D. Weisenberger; Susan L. Slager; Paige M. Bracci

doi:10.1007/s10552-019-01188-w

Blood transfusion history and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis

James R. Cerhan, Eleanor Kane, Claire M. Vajdic, Martha S. Linet, Alain Monnereau, Leslie Bernstein, Silvia de Sanjose, Brian C.H. Chiu, John J. Spinelli, Luigino Dal Maso, Yawei Zhang, Beth R. Larrabee, Wendy Cozen, Alexandra G. Smith, Jacqueline Clavel, Diego Serraino, Tongzhang Zheng, Elizabeth A. Holly, Dennis D. Weisenberger, Susan L. SlagerPaige M. Bracci

Health Sciences Research

Research output: Contribution to journal › Article

1 Scopus citations

Abstract

Purpose: To conduct a pooled analysis assessing the association of blood transfusion with risk of non-Hodgkin lymphoma (NHL). Methods: We used harmonized data from 13 case–control studies (10,805 cases, 14,026 controls) in the InterLymph Consortium. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression, adjusted for study design variables. Results: Among non-Hispanic whites (NHW), history of any transfusion was inversely associated with NHL risk for men (OR 0.74; 95% CI 0.65–0.83) but not women (OR 0.92; 95% CI 0.83–1.03), p_{heterogeneity} = 0.014. Transfusion history was not associated with risk in other racial/ethnic groups. There was no trend with the number of transfusions, time since first transfusion, age at first transfusion, or decade of first transfusion, and further adjustment for socioeconomic status, body mass index, smoking, alcohol use, and HCV seropositivity did not alter the results. Associations for NHW men were stronger in hospital-based (OR 0.56; 95% CI 0.45–0.70) but still apparent in population-based (OR 0.84; 95% CI 0.72–0.98) studies. Conclusions: In the setting of a literature reporting mainly null and some positive associations, and the lack of a clear methodologic explanation for our inverse association restricted to NHW men, the current body of evidence suggests that there is no association of blood transfusion with risk of NHL.

Original language	English (US)
Pages (from-to)	889-900
Number of pages	12
Journal	Cancer Causes and Control
Volume	30
Issue number	8
DOIs	https://doi.org/10.1007/s10552-019-01188-w
State	Published - Aug 1 2019

Keywords

Epidemiology
Etiology
Lymphoma
Pooled analysis
Transfusion

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1007/s10552-019-01188-w

Fingerprint Dive into the research topics of 'Blood transfusion history and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis'. Together they form a unique fingerprint.

Cite this

Cerhan, J. R., Kane, E., Vajdic, C. M., Linet, M. S., Monnereau, A., Bernstein, L., de Sanjose, S., Chiu, B. C. H., Spinelli, J. J., Maso, L. D., Zhang, Y., Larrabee, B. R., Cozen, W., Smith, A. G., Clavel, J., Serraino, D., Zheng, T., Holly, E. A., Weisenberger, D. D., ... Bracci, P. M. (2019). Blood transfusion history and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis. Cancer Causes and Control, 30(8), 889-900. https://doi.org/10.1007/s10552-019-01188-w

Blood transfusion history and risk of non-Hodgkin lymphoma : an InterLymph pooled analysis. / Cerhan, James R.; Kane, Eleanor; Vajdic, Claire M.; Linet, Martha S.; Monnereau, Alain; Bernstein, Leslie; de Sanjose, Silvia; Chiu, Brian C.H.; Spinelli, John J.; Maso, Luigino Dal; Zhang, Yawei; Larrabee, Beth R.; Cozen, Wendy; Smith, Alexandra G.; Clavel, Jacqueline; Serraino, Diego; Zheng, Tongzhang; Holly, Elizabeth A.; Weisenberger, Dennis D.; Slager, Susan L.; Bracci, Paige M.

In: Cancer Causes and Control, Vol. 30, No. 8, 01.08.2019, p. 889-900.

Research output: Contribution to journal › Article

Cerhan, JR, Kane, E, Vajdic, CM, Linet, MS, Monnereau, A, Bernstein, L, de Sanjose, S, Chiu, BCH, Spinelli, JJ, Maso, LD, Zhang, Y, Larrabee, BR, Cozen, W, Smith, AG, Clavel, J, Serraino, D, Zheng, T, Holly, EA, Weisenberger, DD, Slager, SL & Bracci, PM 2019, 'Blood transfusion history and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis', Cancer Causes and Control, vol. 30, no. 8, pp. 889-900. https://doi.org/10.1007/s10552-019-01188-w

Cerhan, James R. ; Kane, Eleanor ; Vajdic, Claire M. ; Linet, Martha S. ; Monnereau, Alain ; Bernstein, Leslie ; de Sanjose, Silvia ; Chiu, Brian C.H. ; Spinelli, John J. ; Maso, Luigino Dal ; Zhang, Yawei ; Larrabee, Beth R. ; Cozen, Wendy ; Smith, Alexandra G. ; Clavel, Jacqueline ; Serraino, Diego ; Zheng, Tongzhang ; Holly, Elizabeth A. ; Weisenberger, Dennis D. ; Slager, Susan L. ; Bracci, Paige M. / Blood transfusion history and risk of non-Hodgkin lymphoma : an InterLymph pooled analysis. In: Cancer Causes and Control. 2019 ; Vol. 30, No. 8. pp. 889-900.

@article{c8b92ec37dc64087b862391da28f2163,

title = "Blood transfusion history and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis",

abstract = "Purpose: To conduct a pooled analysis assessing the association of blood transfusion with risk of non-Hodgkin lymphoma (NHL). Methods: We used harmonized data from 13 case–control studies (10,805 cases, 14,026 controls) in the InterLymph Consortium. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression, adjusted for study design variables. Results: Among non-Hispanic whites (NHW), history of any transfusion was inversely associated with NHL risk for men (OR 0.74; 95% CI 0.65–0.83) but not women (OR 0.92; 95% CI 0.83–1.03), pheterogeneity = 0.014. Transfusion history was not associated with risk in other racial/ethnic groups. There was no trend with the number of transfusions, time since first transfusion, age at first transfusion, or decade of first transfusion, and further adjustment for socioeconomic status, body mass index, smoking, alcohol use, and HCV seropositivity did not alter the results. Associations for NHW men were stronger in hospital-based (OR 0.56; 95% CI 0.45–0.70) but still apparent in population-based (OR 0.84; 95% CI 0.72–0.98) studies. Conclusions: In the setting of a literature reporting mainly null and some positive associations, and the lack of a clear methodologic explanation for our inverse association restricted to NHW men, the current body of evidence suggests that there is no association of blood transfusion with risk of NHL.",

keywords = "Epidemiology, Etiology, Lymphoma, Pooled analysis, Transfusion",

author = "Cerhan, {James R.} and Eleanor Kane and Vajdic, {Claire M.} and Linet, {Martha S.} and Alain Monnereau and Leslie Bernstein and {de Sanjose}, Silvia and Chiu, {Brian C.H.} and Spinelli, {John J.} and Maso, {Luigino Dal} and Yawei Zhang and Larrabee, {Beth R.} and Wendy Cozen and Smith, {Alexandra G.} and Jacqueline Clavel and Diego Serraino and Tongzhang Zheng and Holly, {Elizabeth A.} and Weisenberger, {Dennis D.} and Slager, {Susan L.} and Bracci, {Paige M.}",

year = "2019",

month = aug,

day = "1",

doi = "10.1007/s10552-019-01188-w",

language = "English (US)",

volume = "30",

pages = "889--900",

journal = "Cancer Causes and Control",

issn = "0957-5243",

publisher = "Springer Netherlands",

number = "8",

}

TY - JOUR

T1 - Blood transfusion history and risk of non-Hodgkin lymphoma

T2 - an InterLymph pooled analysis

AU - Cerhan, James R.

AU - Kane, Eleanor

AU - Vajdic, Claire M.

AU - Linet, Martha S.

AU - Monnereau, Alain

AU - Bernstein, Leslie

AU - de Sanjose, Silvia

AU - Chiu, Brian C.H.

AU - Spinelli, John J.

AU - Maso, Luigino Dal

AU - Zhang, Yawei

AU - Larrabee, Beth R.

AU - Cozen, Wendy

AU - Smith, Alexandra G.

AU - Clavel, Jacqueline

AU - Serraino, Diego

AU - Zheng, Tongzhang

AU - Holly, Elizabeth A.

AU - Weisenberger, Dennis D.

AU - Slager, Susan L.

AU - Bracci, Paige M.

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Purpose: To conduct a pooled analysis assessing the association of blood transfusion with risk of non-Hodgkin lymphoma (NHL). Methods: We used harmonized data from 13 case–control studies (10,805 cases, 14,026 controls) in the InterLymph Consortium. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression, adjusted for study design variables. Results: Among non-Hispanic whites (NHW), history of any transfusion was inversely associated with NHL risk for men (OR 0.74; 95% CI 0.65–0.83) but not women (OR 0.92; 95% CI 0.83–1.03), pheterogeneity = 0.014. Transfusion history was not associated with risk in other racial/ethnic groups. There was no trend with the number of transfusions, time since first transfusion, age at first transfusion, or decade of first transfusion, and further adjustment for socioeconomic status, body mass index, smoking, alcohol use, and HCV seropositivity did not alter the results. Associations for NHW men were stronger in hospital-based (OR 0.56; 95% CI 0.45–0.70) but still apparent in population-based (OR 0.84; 95% CI 0.72–0.98) studies. Conclusions: In the setting of a literature reporting mainly null and some positive associations, and the lack of a clear methodologic explanation for our inverse association restricted to NHW men, the current body of evidence suggests that there is no association of blood transfusion with risk of NHL.

AB - Purpose: To conduct a pooled analysis assessing the association of blood transfusion with risk of non-Hodgkin lymphoma (NHL). Methods: We used harmonized data from 13 case–control studies (10,805 cases, 14,026 controls) in the InterLymph Consortium. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression, adjusted for study design variables. Results: Among non-Hispanic whites (NHW), history of any transfusion was inversely associated with NHL risk for men (OR 0.74; 95% CI 0.65–0.83) but not women (OR 0.92; 95% CI 0.83–1.03), pheterogeneity = 0.014. Transfusion history was not associated with risk in other racial/ethnic groups. There was no trend with the number of transfusions, time since first transfusion, age at first transfusion, or decade of first transfusion, and further adjustment for socioeconomic status, body mass index, smoking, alcohol use, and HCV seropositivity did not alter the results. Associations for NHW men were stronger in hospital-based (OR 0.56; 95% CI 0.45–0.70) but still apparent in population-based (OR 0.84; 95% CI 0.72–0.98) studies. Conclusions: In the setting of a literature reporting mainly null and some positive associations, and the lack of a clear methodologic explanation for our inverse association restricted to NHW men, the current body of evidence suggests that there is no association of blood transfusion with risk of NHL.

KW - Epidemiology

KW - Etiology

KW - Lymphoma

KW - Pooled analysis

KW - Transfusion

UR - http://www.scopus.com/inward/record.url?scp=85067073783&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067073783&partnerID=8YFLogxK

U2 - 10.1007/s10552-019-01188-w

DO - 10.1007/s10552-019-01188-w

M3 - Article

C2 - 31165419

AN - SCOPUS:85067073783

VL - 30

SP - 889

EP - 900

JO - Cancer Causes and Control

JF - Cancer Causes and Control

SN - 0957-5243

IS - 8

ER -