Blood transfusion, alcohol use, and anthropometric risk factors for rheumatoid arthritis in older women

James R Cerhan, Kenneth G. Saag, Lindsey A. Criswell, Linda A. Merlino, Ted R. Mikuls

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Objective. To evaluate whether blood transfusion, alcohol use, or anthropometric characteristics are risk factors for rheumatoid arthritis (RA) in older women. Methods. These factors were evaluated in a prospective cohort study that was initiated in 1986, and included 31,336 women aged 55-69 years without a history of RA. Risk factor data were self-reported using a mailed questionnaire. Through 1997, 158 cases of RA meeting at least 4 of 7 American College of Rheumatology criteria were identified and validated by medical record review. The relative risk (RR) and 95% confidence interval (CI) were used as the measure of association, and were adjusted for the potential confounding effects of age, marital status, smoking history, age at menopause, and use of estrogen replacement therapy. Results. History of blood transfusion was inversely associated with RA (multivariate RR = 0.72; 95% CI 0.48-1.08), and this association was stronger for rheumatoid factor (RF) positive disease (RR = 0.59; 95% CI 0.35-1.00). There were no associations for use of medications for hyper- or hypothyroidism or adult onset diabetes. Anthropometric factors (height, weight, body mass index, body fat distribution), leisure time physical activity, and alcohol use were not associated with risk of RA. Conclusion. A history of blood transfusion was inversely associated with RA, particularly RF positive RA. Anthropometric factors, physical activity, and alcohol use did not influence the risk of RA in this cohort of older women.

Original languageEnglish (US)
Pages (from-to)246-254
Number of pages9
JournalJournal of Rheumatology
Volume29
Issue number2
StatePublished - 2002

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Blood Transfusion
Rheumatoid Arthritis
Alcohols
Rheumatoid Factor
Confidence Intervals
Exercise
Body Fat Distribution
Estrogen Replacement Therapy
Leisure Activities
Marital Status
Hyperthyroidism
Menopause
Hypothyroidism
Medical Records
Body Mass Index
Cohort Studies
Smoking
History
Prospective Studies
Weights and Measures

Keywords

  • Alcohol
  • Cohort study
  • Obesity
  • Rheumatoid arthritis
  • Risk factors
  • Transfusion

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Blood transfusion, alcohol use, and anthropometric risk factors for rheumatoid arthritis in older women. / Cerhan, James R; Saag, Kenneth G.; Criswell, Lindsey A.; Merlino, Linda A.; Mikuls, Ted R.

In: Journal of Rheumatology, Vol. 29, No. 2, 2002, p. 246-254.

Research output: Contribution to journalArticle

Cerhan, JR, Saag, KG, Criswell, LA, Merlino, LA & Mikuls, TR 2002, 'Blood transfusion, alcohol use, and anthropometric risk factors for rheumatoid arthritis in older women', Journal of Rheumatology, vol. 29, no. 2, pp. 246-254.
Cerhan, James R ; Saag, Kenneth G. ; Criswell, Lindsey A. ; Merlino, Linda A. ; Mikuls, Ted R. / Blood transfusion, alcohol use, and anthropometric risk factors for rheumatoid arthritis in older women. In: Journal of Rheumatology. 2002 ; Vol. 29, No. 2. pp. 246-254.
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