Blood Pressure Responses to Endovascular Stimulation: A Potential Therapy for Autonomic Disorders With Vasodilatation

Niyada Naksuk, Ammar M. Killu, Vidhushei Yogeswaran, Christopher V. Desimone, Scott H. Suddendorf, Dorothy J. Ladewig, Joanne M. Powers, Sarah Weber, Malini Madhavan, Yong-Mei Cha, Suraj Kapa, Samuel J Asirvatham

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: We have previously shown that sympathetic ganglia stimulation via the renal vein rapidly increases blood pressure. This study further investigated the optimal target sites and effective energy levels for stimulation of the renal vasculatures and nearby sympathetic ganglia for rapid increase in blood pressure. Methods: The pre-study protocol for endovascular stimulations included 2 minutes of stimulation (1–150 V and 10 pulses per second) and at least 2 minutes of rest during poststimulation. If blood pressure and/or heart rate were changed during the stimulation, time to return to baseline was allowed prior to the next stimulation. Results: In 11 acute canine studies, we performed 85 renal artery, 30 renal vein, and 8 hepatic vasculature stimulations. The mean arterial pressure (MAP) rapidly increased during stimulation of renal artery (95 ± 18 mmHg vs. 103 ± 15 mmHg; P < 0.0001), renal vein (90 ± 16 mmHg vs. 102 ± 20 mmHg; P = 0.001), and hepatic vasculatures (74 ± 8 mmHg vs. 82 ± 11 mmHg; P = 0.04). Predictors of a significant increase in MAP were energy >10 V focused on the left renal artery, bilateral renal arteries, and bilateral renal veins (especially the mid segment). Overall, heart rate was unchanged, but muscle fasciculation was observed in 22.0% with an output >10 V (range 15–150 V). Analysis after excluding the stimulations that resulted in fasciculation yielded similar results to the main findings. Conclusions: Stimulation of intra-abdominal vasculatures promptly increased the MAP and thus may be a potential treatment option for hypotension in autonomic disorders. Predictors of optimal stimulation include energy delivery and the site of stimulation (for the renal vasculatures), which informs the design of subsequent research.

Original languageEnglish (US)
Pages (from-to)1078-1085
Number of pages8
JournalJournal of Cardiovascular Electrophysiology
Volume27
Issue number9
DOIs
StatePublished - Sep 1 2016

Fingerprint

Renal Artery
Vasodilation
Renal Veins
Fasciculation
Blood Pressure
Sympathetic Ganglia
Arterial Pressure
Heart Rate
Kidney
Therapeutics
Hypotension
Canidae
Research Design
Muscles
Liver

Keywords

  • autonomic disorder
  • blood pressure
  • ganglia stimulation
  • neurocardiogenic syncope
  • reflex syncope
  • renal nerve stimulation
  • sympathetic stimulation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Blood Pressure Responses to Endovascular Stimulation : A Potential Therapy for Autonomic Disorders With Vasodilatation. / Naksuk, Niyada; Killu, Ammar M.; Yogeswaran, Vidhushei; Desimone, Christopher V.; Suddendorf, Scott H.; Ladewig, Dorothy J.; Powers, Joanne M.; Weber, Sarah; Madhavan, Malini; Cha, Yong-Mei; Kapa, Suraj; Asirvatham, Samuel J.

In: Journal of Cardiovascular Electrophysiology, Vol. 27, No. 9, 01.09.2016, p. 1078-1085.

Research output: Contribution to journalArticle

Naksuk, N, Killu, AM, Yogeswaran, V, Desimone, CV, Suddendorf, SH, Ladewig, DJ, Powers, JM, Weber, S, Madhavan, M, Cha, Y-M, Kapa, S & Asirvatham, SJ 2016, 'Blood Pressure Responses to Endovascular Stimulation: A Potential Therapy for Autonomic Disorders With Vasodilatation', Journal of Cardiovascular Electrophysiology, vol. 27, no. 9, pp. 1078-1085. https://doi.org/10.1111/jce.13018
Naksuk, Niyada ; Killu, Ammar M. ; Yogeswaran, Vidhushei ; Desimone, Christopher V. ; Suddendorf, Scott H. ; Ladewig, Dorothy J. ; Powers, Joanne M. ; Weber, Sarah ; Madhavan, Malini ; Cha, Yong-Mei ; Kapa, Suraj ; Asirvatham, Samuel J. / Blood Pressure Responses to Endovascular Stimulation : A Potential Therapy for Autonomic Disorders With Vasodilatation. In: Journal of Cardiovascular Electrophysiology. 2016 ; Vol. 27, No. 9. pp. 1078-1085.
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abstract = "Background: We have previously shown that sympathetic ganglia stimulation via the renal vein rapidly increases blood pressure. This study further investigated the optimal target sites and effective energy levels for stimulation of the renal vasculatures and nearby sympathetic ganglia for rapid increase in blood pressure. Methods: The pre-study protocol for endovascular stimulations included 2 minutes of stimulation (1–150 V and 10 pulses per second) and at least 2 minutes of rest during poststimulation. If blood pressure and/or heart rate were changed during the stimulation, time to return to baseline was allowed prior to the next stimulation. Results: In 11 acute canine studies, we performed 85 renal artery, 30 renal vein, and 8 hepatic vasculature stimulations. The mean arterial pressure (MAP) rapidly increased during stimulation of renal artery (95 ± 18 mmHg vs. 103 ± 15 mmHg; P < 0.0001), renal vein (90 ± 16 mmHg vs. 102 ± 20 mmHg; P = 0.001), and hepatic vasculatures (74 ± 8 mmHg vs. 82 ± 11 mmHg; P = 0.04). Predictors of a significant increase in MAP were energy >10 V focused on the left renal artery, bilateral renal arteries, and bilateral renal veins (especially the mid segment). Overall, heart rate was unchanged, but muscle fasciculation was observed in 22.0{\%} with an output >10 V (range 15–150 V). Analysis after excluding the stimulations that resulted in fasciculation yielded similar results to the main findings. Conclusions: Stimulation of intra-abdominal vasculatures promptly increased the MAP and thus may be a potential treatment option for hypotension in autonomic disorders. Predictors of optimal stimulation include energy delivery and the site of stimulation (for the renal vasculatures), which informs the design of subsequent research.",
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T2 - A Potential Therapy for Autonomic Disorders With Vasodilatation

AU - Naksuk, Niyada

AU - Killu, Ammar M.

AU - Yogeswaran, Vidhushei

AU - Desimone, Christopher V.

AU - Suddendorf, Scott H.

AU - Ladewig, Dorothy J.

AU - Powers, Joanne M.

AU - Weber, Sarah

AU - Madhavan, Malini

AU - Cha, Yong-Mei

AU - Kapa, Suraj

AU - Asirvatham, Samuel J

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N2 - Background: We have previously shown that sympathetic ganglia stimulation via the renal vein rapidly increases blood pressure. This study further investigated the optimal target sites and effective energy levels for stimulation of the renal vasculatures and nearby sympathetic ganglia for rapid increase in blood pressure. Methods: The pre-study protocol for endovascular stimulations included 2 minutes of stimulation (1–150 V and 10 pulses per second) and at least 2 minutes of rest during poststimulation. If blood pressure and/or heart rate were changed during the stimulation, time to return to baseline was allowed prior to the next stimulation. Results: In 11 acute canine studies, we performed 85 renal artery, 30 renal vein, and 8 hepatic vasculature stimulations. The mean arterial pressure (MAP) rapidly increased during stimulation of renal artery (95 ± 18 mmHg vs. 103 ± 15 mmHg; P < 0.0001), renal vein (90 ± 16 mmHg vs. 102 ± 20 mmHg; P = 0.001), and hepatic vasculatures (74 ± 8 mmHg vs. 82 ± 11 mmHg; P = 0.04). Predictors of a significant increase in MAP were energy >10 V focused on the left renal artery, bilateral renal arteries, and bilateral renal veins (especially the mid segment). Overall, heart rate was unchanged, but muscle fasciculation was observed in 22.0% with an output >10 V (range 15–150 V). Analysis after excluding the stimulations that resulted in fasciculation yielded similar results to the main findings. Conclusions: Stimulation of intra-abdominal vasculatures promptly increased the MAP and thus may be a potential treatment option for hypotension in autonomic disorders. Predictors of optimal stimulation include energy delivery and the site of stimulation (for the renal vasculatures), which informs the design of subsequent research.

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