Blood pressure regulation in humans: Calculation of an "error signal" in control of sympathetic nerve activity

Erica A. Wehrwein, Michael Joseph Joyner, Emma C J Hart, B. Gunnar Wallin, Tomas Karlsson, Nisha Charkoudian

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Within an individual, diastolic blood pressure (DBP) is negatively related to sympathetic burst incidence, such that lower pressure is associated with high burst incidence. Our goal was to explore the use of a calculation of a DBP "error signal" in the control of muscle sympathetic nerve activity in men and women. Baseline muscle sympathetic nerve activity was measured in healthy young men (n=22) and women (n=28). Women had significantly lower muscle sympathetic nerve activity than men (29±3 versus 43±2 bursts per 100 heartbeats; P<0.05). For each individual, the DBP at which there is a 50% likelihood of a muscle sympathetic nerve activity burst, the "T50" value, was calculated. Mean DBP was subtracted from the T50 blood pressure as an approximate error signal for burst activation. Error signal was negative in both sexes, indicating that DBP in both sexes was higher than the DBP value associated with a 50% burst likelihood. However, average error signal was significantly larger in women (-4±2 mm Hg) than in men (-1±0 mm Hg; P<0.05 versus women). We conclude that women operate at a mean DBP greater than their T50 compared with men, and this may be a contributing factor to low basal muscle sympathetic nerve activity in women. The relationship between error signal and burst incidence may provide important insight into the control of muscle sympathetic nerve activity across sexes and in various populations.

Original languageEnglish (US)
Pages (from-to)264-269
Number of pages6
JournalHypertension
Volume55
Issue number2
DOIs
StatePublished - Feb 2010

Fingerprint

Blood Pressure
Muscles
Incidence
Hypertension
Pressure

Keywords

  • Baroreflex
  • MSNA
  • Sex
  • Sympathetic
  • Threshold

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Blood pressure regulation in humans : Calculation of an "error signal" in control of sympathetic nerve activity. / Wehrwein, Erica A.; Joyner, Michael Joseph; Hart, Emma C J; Wallin, B. Gunnar; Karlsson, Tomas; Charkoudian, Nisha.

In: Hypertension, Vol. 55, No. 2, 02.2010, p. 264-269.

Research output: Contribution to journalArticle

Wehrwein, Erica A. ; Joyner, Michael Joseph ; Hart, Emma C J ; Wallin, B. Gunnar ; Karlsson, Tomas ; Charkoudian, Nisha. / Blood pressure regulation in humans : Calculation of an "error signal" in control of sympathetic nerve activity. In: Hypertension. 2010 ; Vol. 55, No. 2. pp. 264-269.
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