Blood pressure in early autosomal dominant polycystic kidney disease

Robert W. Schrier, Kaleab Z. Abebe, Ronald D. Perrone, Vicente E. Torres, William E. Braun, Theodore I. Steinman, Franz T. Winklhofer, Godela Brosnahan, Peter G. Czarnecki, Marie C. Hogan, Dana C. Miskulin, Frederic F. Rahbari-Oskoui, Jared J. Grantham, Peter C. Harris, Michael F. Flessner, Kyongtae T. Bae, Charity G. Moore, Arlene B. Chapman

Research output: Contribution to journalArticle

221 Scopus citations

Abstract

BACKGROUND Hypertension is common in autosomal dominant polycystic kidney disease (ADPKD) and is associated with increased total kidney volume, activation of the renin-angiotensin- aldosterone system, and progression of kidney disease.

METHODS In this double-blind, placebo-controlled trial, we randomly assigned 558 hypertensive participants with ADPKD (15 to 49 years of age, with an estimated glomerular filtration rate [GFR] >60 ml per minute per 1.73 m2 of body-surface area) to either a standard blood-pressure target (120/70 to 130/80 mm Hg) or a low blood-pressure target (95/60 to 110/75 mm Hg) and to either an angiotensin-converting-enzyme inhibitor (lisinopril) plus an angiotensin-receptor blocker (telmisartan) or lisinopril plus placebo. The primary outcome was the annual percentage change in the total kidney volume.

RESULTS The annual percentage increase in total kidney volume was significantly lower in the low-blood-pressure group than in the standard-blood-pressure group (5.6% vs. 6.6%, P = 0.006), without significant differences between the lisinopril-telmisartan group and the lisinopril-placebo group. The rate of change in estimated GFR was similar in the two medication groups, with a negative slope difference in the short term in the low-blood-pressure group as compared with the standard-blood-pressure group (P<0.001) and a marginally positive slope difference in the long term (P = 0.05). The left-ventricular-mass index decreased more in the low-blood-pressure group than in the standard-blood-pressure group (-1.17 vs. -0.57 g per square meter per year, P<0.001); urinary albumin excretion was reduced by 3.77% with the low-pressure target and increased by 2.43% with the standard target (P<0.001). Dizziness and light-headedness were more common in the low-blood-pressure group than in the standard-blood-pressure group (80.7% vs. 69.4%, P = 0.002).

CONCLUSIONS In early ADPKD, the combination of lisinopril and telmisartan did not significantly alter the rate of increase in total kidney volume. As compared with standard bloodpressure control, rigorous blood-pressure control was associated with a slower increase in total kidney volume, no overall change in the estimated GFR, a greater decline in the left-ventricular-mass index, and greater reduction in urinary albumin excretion.

Original languageEnglish (US)
Pages (from-to)2255-2266
Number of pages12
JournalNew England Journal of Medicine
Volume371
Issue number24
DOIs
StatePublished - Dec 11 2014

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Schrier, R. W., Abebe, K. Z., Perrone, R. D., Torres, V. E., Braun, W. E., Steinman, T. I., Winklhofer, F. T., Brosnahan, G., Czarnecki, P. G., Hogan, M. C., Miskulin, D. C., Rahbari-Oskoui, F. F., Grantham, J. J., Harris, P. C., Flessner, M. F., Bae, K. T., Moore, C. G., & Chapman, A. B. (2014). Blood pressure in early autosomal dominant polycystic kidney disease. New England Journal of Medicine, 371(24), 2255-2266. https://doi.org/10.1056/NEJMoa1402685