Blood pressure and in-hospital outcomes in patients presenting with ischaemic stroke

Aims Post-stroke hypertension is associated with poor short-term outcome, although the results have been conflicting. Our objective was to evaluate the association of blood pressure (BP) and in-hospital outcomes in patients with acute ischaemic stroke. Methods and results Patients in the Get With The Guidelines-Stroke registry with acute ischaemic stroke were included. Admission systolic and diastolic BP was used to compute mean arterial pressure (MAP) and pulse pressure (PP). The outcomes of interest were: in-hospital mortality, not discharged home, inability to ambulate independently at discharge and haemorrhagic complications due to thrombolytic therapy. A total of 309 611 patients with an ischaemic stroke were included. There was a J-shaped/U-shaped relationship between systolic BP and outcomes. Both lower and higher systolic BP values, compared with a central reference value, had higher risk of in-hospital death [e.g. adjusted odds ratio (95% confidence interval) (OR[CI])= 1.16[1.13-1.20] for 120 vs. 150mmHg and 1.24[1.19-1.30] for 200 vs. 150mmHg], not discharged home (OR[CI]=1.11[1.09-1.13] for 120 vs. 150mmHg and 1.15[1.12-1.18] for 200 vs. 150mmHg), inability to ambulate independently at discharge (OR[CI]= 1.16[1.13-1.18] for 120 vs. 150mmHg and 1.09[1.06-1.11] for 200 vs. 150mmHg). However, risk of haemorrhagic complications of thrombolytic therapy was lower with lower systolic BP (OR[CI]= 0.89[0.83-0.97] for 120 vs. 150mmHg), while higher with higher systolic BP (OR[CI]= 1.21[1.11-1.32] for 200 vs. 150 mmHg). The results were largely similar for admission diastolic BP, MAP, and PP. Conclusion In patients hospitalized with ischaemic stroke, J-shaped, or U-shaped relationships were observed between BP variables and short-term outcomes. However, haemorrhagic complications with thrombolytic therapy were lower with lower BP.