Blood oxygen level-dependent measurement of acute intra-renal ischemia

Laurent Juillard, Lilach O Lerman, David G. Kruger, John A. Haas, Brian C. Rucker, Jason A. Polzin, Stephen J Riederer, Juan C. Romero

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Background. Ischemic nephropathy is a common cause of end-stage renal disease. Exploration of the mechanisms of deterioration of renal function is limited due to lack of noninvasive techniques available to study the single kidney. The Blood Oxygen Level-Dependent (BOLD) MRI method can measure deoxyhemoglobin and therefore indirectly estimates renal oxygen content, but has never been evaluated in renal artery stenosis (RAS). This study was therefore designed to test if BOLD can detect the characteristic of renal hypoxia induced by RAS. Methods. RAS was induced in 8 pigs using an occluder placed around the right renal artery. Renal blood flow (RBF) was measured continuously with an ultrasound probe. BOLD signal was measured bilaterally in the cortex and medulla (as the slope of the logarithm of MR signal) at baseline and at the lower limit of RBF autoregulation. The measurements were then repeated during six sequential graded decreases in RBF (80 to 0% of baseline) and during recovery. Results. During the control period, BOLD signals were not significantly different between the right and the left kidneys. In the occluded kidney, BOLD signal of the cortex (19.3 ± 1.9/s) and the medulla (17.3 ± 2.0/s) increased during occlusion gradually and significantly (P < 0.0001) to a maximum (at total occlusion) of 33.8 ± 2.0/s (+79%) and 29. 8 ± 2.3/s (+78%), respectively, and returned to baseline values during recovery. Conclusion. This study shows that the BOLD technique can noninvasively detect change in intra-renal oxygenation during an acute reduction of RBF. This study provides a strong rationale for developing the BOLD method for the detection and evaluation of renal hypoxia induced by RAS, which may be potentially applicable in humans.

Original languageEnglish (US)
Pages (from-to)944-950
Number of pages7
JournalKidney International
Volume65
Issue number3
DOIs
StatePublished - Mar 2004

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Ischemia
Oxygen
Kidney
Renal Artery Obstruction
Renal Circulation
Hematologic Tests
Renal Artery
Chronic Kidney Failure
Homeostasis
Swine

Keywords

  • Blood oxygen level-dependent
  • Magnetic resonance imaging
  • Pig
  • Renal artery stenosis
  • Renal blood flow

ASJC Scopus subject areas

  • Nephrology

Cite this

Juillard, L., Lerman, L. O., Kruger, D. G., Haas, J. A., Rucker, B. C., Polzin, J. A., ... Romero, J. C. (2004). Blood oxygen level-dependent measurement of acute intra-renal ischemia. Kidney International, 65(3), 944-950. https://doi.org/10.1111/j.1523-1755.2004.00469.x

Blood oxygen level-dependent measurement of acute intra-renal ischemia. / Juillard, Laurent; Lerman, Lilach O; Kruger, David G.; Haas, John A.; Rucker, Brian C.; Polzin, Jason A.; Riederer, Stephen J; Romero, Juan C.

In: Kidney International, Vol. 65, No. 3, 03.2004, p. 944-950.

Research output: Contribution to journalArticle

Juillard, L, Lerman, LO, Kruger, DG, Haas, JA, Rucker, BC, Polzin, JA, Riederer, SJ & Romero, JC 2004, 'Blood oxygen level-dependent measurement of acute intra-renal ischemia', Kidney International, vol. 65, no. 3, pp. 944-950. https://doi.org/10.1111/j.1523-1755.2004.00469.x
Juillard, Laurent ; Lerman, Lilach O ; Kruger, David G. ; Haas, John A. ; Rucker, Brian C. ; Polzin, Jason A. ; Riederer, Stephen J ; Romero, Juan C. / Blood oxygen level-dependent measurement of acute intra-renal ischemia. In: Kidney International. 2004 ; Vol. 65, No. 3. pp. 944-950.
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AU - Haas, John A.

AU - Rucker, Brian C.

AU - Polzin, Jason A.

AU - Riederer, Stephen J

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