Blood oxygen level-dependent (BOLD) MRI in renovascular hypertension

Monika L. Gloviczki, Lilach O Lerman, Stephen C Textor

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Establishing whether large vessel occlusive disease threatens tissue oxygenation and viability in the post-stenotic kidney is difficult for clinicians. Development of blood oxygen level-dependent (BOLD) MRI methods can allow functional evaluation of regional differences in deoxyhemoglobin levels within the kidney without requiring contrast. The complex renal circulation normally provides a gradient of oxygenation from a highly vascular cortex to much reduced levels in the deep sections of medulla, dependent upon adjustments in renal afferent arterioles, oxygen consumption related to solute transport, and arteriovenous shunting related to the juxtaposition of descending and ascending vasa recta. Studies with BOLD imaging have identified adaptation to substantial reductions in renal blood flow, volume, and glomerular filtration rate in post-stenotic kidneys that preserves medullary and cortical oxygenation during medical therapy. However, extreme vascular compromise overwhelms these adaptive changes and leads to cortical hypoxia and microvascular injury.

Original languageEnglish (US)
Pages (from-to)370-377
Number of pages8
JournalCurrent Hypertension Reports
Volume13
Issue number5
DOIs
StatePublished - Oct 2011

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Keywords

  • BOLD MRI
  • Hypoxia
  • Ischemic nephropathy
  • Kidney
  • Magnetic resonance imaging
  • Oxidative stress
  • Oxygen
  • Renal artery stenosis
  • Renovascular hypertension

ASJC Scopus subject areas

  • Internal Medicine

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