Blood lead level and its association with body mass index and obesity in China - Results from SPECT-China study

Ningjian Wang, Chi Chen, Xiaomin Nie, Bing Han, Qin Li, Yi Chen, Chunfang Zhu, Yingchao Chen, Fangzhen Xia, Zhen Cang, Meng Lu, Ying Meng, Hualing Zhai, Dongping Lin, Shiyong Cui, Michael Dennis Jensen, Yingli Lu

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Abstract

We aimed to report environmental and blood lead level (BLL) in China, and investigate the relationship of BLL with body mass index (BMI) and obesity. 5558 subjects were enrolled from 16 sites in China. BLL was measured by atomic absorption spectrometry. Obesity was defined as BMI ‰ 30 kg/m 2. Median (interquartile range) of BLL was 44.00 1/4g/L (29.00-62.16) for men and 37.79 1/4g/L (25.13-54.35) for women, about twice higher than in U.S. population. Subjects in rural and high-economic-status areas had significantly greater BLL (P <0.001). However, in these areas, the lead levels in drinking water, river water and rice were comparable to or significantly lower than those in urban and low-economic-status areas. After adjustment for age, urbanization, economic status and metabolic factors, BLL was independently associated with BMI in women (P for trend <0.001), but not in men. In fully adjusted model, increased quartiles of BLL were associated with significantly increased odds ratios of obesity (P for trend <0.01) in women. In conclusion, BLLs in Chinese adults were much higher than in developed countries. There was a sex-specific association between BLL and BMI. Elevated BLL does not appear to be associated with lead levels in drinking water or rice, suggesting some other exposure source.

Original languageEnglish (US)
Article number18299
JournalScientific Reports
Volume5
DOIs
StatePublished - Dec 14 2015

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Single-Photon Emission-Computed Tomography
China
Body Mass Index
Obesity
Economics
Drinking Water
Lead
Urbanization
Developed Countries
Rivers
Spectrum Analysis
Odds Ratio
Water
Population

ASJC Scopus subject areas

  • General

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Blood lead level and its association with body mass index and obesity in China - Results from SPECT-China study. / Wang, Ningjian; Chen, Chi; Nie, Xiaomin; Han, Bing; Li, Qin; Chen, Yi; Zhu, Chunfang; Chen, Yingchao; Xia, Fangzhen; Cang, Zhen; Lu, Meng; Meng, Ying; Zhai, Hualing; Lin, Dongping; Cui, Shiyong; Jensen, Michael Dennis; Lu, Yingli.

In: Scientific Reports, Vol. 5, 18299, 14.12.2015.

Research output: Contribution to journalArticle

Wang, N, Chen, C, Nie, X, Han, B, Li, Q, Chen, Y, Zhu, C, Chen, Y, Xia, F, Cang, Z, Lu, M, Meng, Y, Zhai, H, Lin, D, Cui, S, Jensen, MD & Lu, Y 2015, 'Blood lead level and its association with body mass index and obesity in China - Results from SPECT-China study', Scientific Reports, vol. 5, 18299. https://doi.org/10.1038/srep18299
Wang, Ningjian ; Chen, Chi ; Nie, Xiaomin ; Han, Bing ; Li, Qin ; Chen, Yi ; Zhu, Chunfang ; Chen, Yingchao ; Xia, Fangzhen ; Cang, Zhen ; Lu, Meng ; Meng, Ying ; Zhai, Hualing ; Lin, Dongping ; Cui, Shiyong ; Jensen, Michael Dennis ; Lu, Yingli. / Blood lead level and its association with body mass index and obesity in China - Results from SPECT-China study. In: Scientific Reports. 2015 ; Vol. 5.
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