Blood group antigens and antibodies in human brain tumor cysts

K. J. Murray, Neil Elliot Kay, S. D. Douglas

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cyst fluids from 12 human brain tumors were studied for their blood-group content and compared to autologous saliva, serum, and cerebrospinal fluid (CSF). Lewis(a) substance, which is a fucolipid, was present in four of 12 cysts studied. Lewis(b), which differs from Lewis(a) by a single fucose, was found in eight of 12 sera and/or saliva and in one CSF specimen; Lewis(b) substance, however, was not detected in any corresponding cyst fluids. Isohemagglutinins, blood-group antibodies anti-A and/or anti-B, were present in nine of nine cyst fluids studied, were of lower titers as compared to autologous serum, and occurred as either IgG or IgM immunoglobulins. The results further delineate the biochemical requirements necessary for molecular penetration into human brain-tumor cysts.

Original languageEnglish (US)
Pages (from-to)164-168
Number of pages5
JournalJournal of Neurosurgery
Volume48
Issue number2
StatePublished - 1978
Externally publishedYes

Fingerprint

Cyst Fluid
Blood Group Antigens
Brain Neoplasms
Cysts
Saliva
Cerebrospinal Fluid
Antibodies
Serum
Fucose
Hemagglutinins
Immunoglobulin M
Immunoglobulins
Anti-Idiotypic Antibodies
Immunoglobulin G

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Blood group antigens and antibodies in human brain tumor cysts. / Murray, K. J.; Kay, Neil Elliot; Douglas, S. D.

In: Journal of Neurosurgery, Vol. 48, No. 2, 1978, p. 164-168.

Research output: Contribution to journalArticle

Murray, KJ, Kay, NE & Douglas, SD 1978, 'Blood group antigens and antibodies in human brain tumor cysts', Journal of Neurosurgery, vol. 48, no. 2, pp. 164-168.
Murray, K. J. ; Kay, Neil Elliot ; Douglas, S. D. / Blood group antigens and antibodies in human brain tumor cysts. In: Journal of Neurosurgery. 1978 ; Vol. 48, No. 2. pp. 164-168.
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