TY - JOUR
T1 - Blood flow imaging through detection of temporal variations in magnetization
AU - Wolf, Ronald L.
AU - Richardson, Donna B.
AU - LaPlante, Christine C.
AU - Huston, John
AU - Riederer, Stephen J.
AU - Ehman, Richard L.
PY - 1992/11
Y1 - 1992/11
N2 - Two hypotheses were tested: (a) that view-to-view variations in bulk phase and modulus of magnetization in vascular volume elements can indicate the presence of disordered blood flow, and (b) that a substantial loss of signal intensity on magnetic resonance (MR) angiograms of post-stenotic regions is due to view-to-view changes in magnetization. To test these hypotheses, a technique was developed in which view-to-view variations in transverse magnetization were used to create angiographic projection images, which showed only disordered flow (disordered flow maps) in vitro and in vivo. In phantom studies, this technique recovered signal intensity downstream from stenoses. A combination of disordered flow maps with morphologic images improved visualization of stenotic regions and provided information on characteristics of local flow. These results show that view-to-view variations in transverse magnetization occur in regions of disordered flow and are an important cause of loss of signal intensity. This technique can provide information about dynamic blood flow and improve depiction of anatomic structures on MR angiograms.
AB - Two hypotheses were tested: (a) that view-to-view variations in bulk phase and modulus of magnetization in vascular volume elements can indicate the presence of disordered blood flow, and (b) that a substantial loss of signal intensity on magnetic resonance (MR) angiograms of post-stenotic regions is due to view-to-view changes in magnetization. To test these hypotheses, a technique was developed in which view-to-view variations in transverse magnetization were used to create angiographic projection images, which showed only disordered flow (disordered flow maps) in vitro and in vivo. In phantom studies, this technique recovered signal intensity downstream from stenoses. A combination of disordered flow maps with morphologic images improved visualization of stenotic regions and provided information on characteristics of local flow. These results show that view-to-view variations in transverse magnetization occur in regions of disordered flow and are an important cause of loss of signal intensity. This technique can provide information about dynamic blood flow and improve depiction of anatomic structures on MR angiograms.
KW - Blood, flow dynamics, 1721.1214, 1721.99
KW - Magnetic resonance (MR), image processing
KW - Magnetic resonance (MR), vascular studies, 1721.99
KW - Phantoms
UR - http://www.scopus.com/inward/record.url?scp=0026953789&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026953789&partnerID=8YFLogxK
U2 - 10.1148/radiology.185.2.1410373
DO - 10.1148/radiology.185.2.1410373
M3 - Article
C2 - 1410373
AN - SCOPUS:0026953789
SN - 0033-8419
VL - 185
SP - 559
EP - 567
JO - Radiology
JF - Radiology
IS - 2
ER -