TY - JOUR
T1 - Block of neurotensin receptor down-regulation by an aminosteroid in N1E-115 cells
AU - Yamada, Mitsuhiko
AU - Yamada, Misa
AU - Richelson, Elliott
PY - 1992/6/5
Y1 - 1992/6/5
N2 - We have demonstrated that the aminosteroid, U-73122 (1-{6-{[17ß-3-methoxyestra-1,3,5(10)-trien-17-yl]amino}hexyl}1H-pyrrole-2,5-dione) blocks agonist induced down-regulation of neurotensin receptors in murine neuroblastoma clone N1E-115 cells. U 73122 is known to inhibit polyphosphoinositide hydrolysis by affecting the coupling of GTP-binding proteins. Our results may indicate that GTP-binding proteins play a role in the mechanism of down-regulation of the neurotensin receptor.
AB - We have demonstrated that the aminosteroid, U-73122 (1-{6-{[17ß-3-methoxyestra-1,3,5(10)-trien-17-yl]amino}hexyl}1H-pyrrole-2,5-dione) blocks agonist induced down-regulation of neurotensin receptors in murine neuroblastoma clone N1E-115 cells. U 73122 is known to inhibit polyphosphoinositide hydrolysis by affecting the coupling of GTP-binding proteins. Our results may indicate that GTP-binding proteins play a role in the mechanism of down-regulation of the neurotensin receptor.
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U2 - 10.1016/0922-4106(92)90183-V
DO - 10.1016/0922-4106(92)90183-V
M3 - Article
C2 - 1322308
AN - SCOPUS:0026717875
SN - 0922-4106
VL - 226
SP - 187
EP - 188
JO - European Journal of Pharmacology: Molecular Pharmacology
JF - European Journal of Pharmacology: Molecular Pharmacology
IS - 2
ER -