Block of neurotensin receptor down-regulation by an aminosteroid in N1E-115 cells

Mitsuhiko Yamada, Misa Yamada, Elliott Richelson

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

We have demonstrated that the aminosteroid, U-73122 (1-{6-{[17ß-3-methoxyestra-1,3,5(10)-trien-17-yl]amino}hexyl}1H-pyrrole-2,5-dione) blocks agonist induced down-regulation of neurotensin receptors in murine neuroblastoma clone N1E-115 cells. U 73122 is known to inhibit polyphosphoinositide hydrolysis by affecting the coupling of GTP-binding proteins. Our results may indicate that GTP-binding proteins play a role in the mechanism of down-regulation of the neurotensin receptor.

Original languageEnglish (US)
Pages (from-to)187-188
Number of pages2
JournalEuropean Journal of Pharmacology: Molecular Pharmacology
Volume226
Issue number2
DOIs
StatePublished - Jun 5 1992

ASJC Scopus subject areas

  • Pharmacology

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