TY - JOUR
T1 - Bloating in constipation
T2 - Relevance of intraluminal gas handling
AU - Houghton, Lesley A.
N1 - Funding Information:
The author has received remuneration for advice, and the department at the University of Manchester, UK has also received financial support from Novartis Pharmaceuticaals, GlaxoSmithKline, Pfizer, Solvay Pharmaceuticals, Danone Research, Clasado Ltd, Norgine, Kellogg’s UK, and One Pharma UK Ltd, and at the Mayo Clinic, Florida, USA from Edusa Pharmaceuticals Inc. and Boehringer Ingelheim Pharma GmbH & Co.
PY - 2011/2
Y1 - 2011/2
N2 - The symptom of bloating and sometimes associated increase in abdominal girth (distension) is often described by patients as very intrusive, significantly impacting their quality of life. Indeed many patients rank it as their most bothersome symptom, even above abdominal pain. Despite this fewer patients appear to seek medical attention for this problem compared with other gastrointestinal symptoms. This has been attributed to the fact that most sufferers usually have other symptoms, such as abdominal pain, which they may perceive as potentially more serious, and hence seek preferential medical advice and treatment. This review aims to clarify the meaning of the terms bloating and distension, explores their association with constipation, and discusses possible pathophysiologies, in particular the relevance of intraluminal gas handling.
AB - The symptom of bloating and sometimes associated increase in abdominal girth (distension) is often described by patients as very intrusive, significantly impacting their quality of life. Indeed many patients rank it as their most bothersome symptom, even above abdominal pain. Despite this fewer patients appear to seek medical attention for this problem compared with other gastrointestinal symptoms. This has been attributed to the fact that most sufferers usually have other symptoms, such as abdominal pain, which they may perceive as potentially more serious, and hence seek preferential medical advice and treatment. This review aims to clarify the meaning of the terms bloating and distension, explores their association with constipation, and discusses possible pathophysiologies, in particular the relevance of intraluminal gas handling.
KW - Bloating
KW - Constipation
KW - Distension
UR - http://www.scopus.com/inward/record.url?scp=79952423170&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952423170&partnerID=8YFLogxK
U2 - 10.1016/j.bpg.2010.12.009
DO - 10.1016/j.bpg.2010.12.009
M3 - Article
C2 - 21382585
AN - SCOPUS:79952423170
SN - 1521-6918
VL - 25
SP - 141
EP - 150
JO - Best Practice and Research: Clinical Gastroenterology
JF - Best Practice and Research: Clinical Gastroenterology
IS - 1
ER -