Bladder outlet obstruction by so-called lymphomatoid granulomatosis (angiocentric lymphoma)

Lymphomatoid granulomatosis is an angiocentric, lymphoproliferative disease of the lung, which frequently involves extrapulmonary sites. Controversy persists over whether this process represents malignant lymphoma from its inception. Historically, the disease generally carries a poor prognosis but aggressive chemotherapy has resulted in improved survival. We describe a patient who presented with bladder outlet obstruction resulting from prostatic infiltration by this angiocentric lymphoproliferative disease. The clinical manifestations, pathologic appearance and therapeutic options are reviewed.