BK Virus-Associated Nephropathy in a Patient With AIDS

William R. Sukov, Matthew Lewin, Sanjeev M Sethi, Thomas A. Rakowski, Donna J. Lager

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The BK virus is a ubiquitous member of the group of human polyoma viruses that commonly is reactivated in the setting of immunosuppression related to renal transplantation, which results in tubulointerstitial nephritis and allograft dysfunction. BK virus-associated nephropathy occurring in association with human immunodeficiency virus infection and acquired immunodeficiency syndrome (AIDS) was reported only rarely. We describe the case of a 43-year-old man with AIDS presenting with nonoliguric renal failure. The renal biopsy specimen showed tubulointerstitial nephritis and renal tubular cell changes consistent with BK viral inclusions. Results of in situ hybridization for BK viral DNA were positive and showed tubular cell intranuclear inclusions. To our knowledge, this represents the third case of AIDS-associated BK virus-associated nephropathy diagnosed by means of biopsy.

Original languageEnglish (US)
JournalAmerican Journal of Kidney Diseases
Volume51
Issue number4
DOIs
StatePublished - Apr 2008

Fingerprint

BK Virus
Interstitial Nephritis
Acquired Immunodeficiency Syndrome
Satellite Viruses
Kidney
Biopsy
Intranuclear Inclusion Bodies
Polyomavirus
Viral DNA
Virus Diseases
Kidney Transplantation
Immunosuppression
In Situ Hybridization
Renal Insufficiency
Allografts
HIV

Keywords

  • acquired immunodeficiency syndrome (AIDS)
  • BK virus
  • human immunodeficiency virus (HIV)
  • interstitial nephritis

ASJC Scopus subject areas

  • Nephrology

Cite this

BK Virus-Associated Nephropathy in a Patient With AIDS. / Sukov, William R.; Lewin, Matthew; Sethi, Sanjeev M; Rakowski, Thomas A.; Lager, Donna J.

In: American Journal of Kidney Diseases, Vol. 51, No. 4, 04.2008.

Research output: Contribution to journalArticle

Sukov, William R. ; Lewin, Matthew ; Sethi, Sanjeev M ; Rakowski, Thomas A. ; Lager, Donna J. / BK Virus-Associated Nephropathy in a Patient With AIDS. In: American Journal of Kidney Diseases. 2008 ; Vol. 51, No. 4.
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