Bisalbuminemia in chronic kidney disease

A. Ahsan Ejaz, Murli Krishna, Andrew Wasiluk, Janice D. Knight

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Hereditary and acquired bisalbuminemia, in which the serum contains an albumin variant differing from albumin A by single amino-acid substitutions, have been reported in different races or ethnic groups and in association with various pathologic states. The importance of this rare condition in the pathophysiology of established diseases is uncertain. We evaluated a 68-year-old woman with chronic kidney disease who presented with worsened serum creatinine concentration despite lack of dietary or medical changes. Serum protein electrophoresis was performed with an automated rapid electrophoresis system, Bisalbuminemia was noted as an incidental finding on serum protein electrophoresis. The serum creatinine level stabilized with dietary protein restriction and a β-blocking agent/ diuretic combination for blood pressure control. Although the possibility that some physiologic or pharmacologic substances may not bind to abnormal albumin variants as well as they bind to normal albumin should not be discounted, the finding of bisalbuminemia did not influence the diagnosis, management, course, or prognosis of chronic kidney disease. The role of persistent bisalbuminemia in renal disease is uncertain.

Original languageEnglish (US)
Pages (from-to)270-273
Number of pages4
JournalClinical and Experimental Nephrology
Volume8
Issue number3
DOIs
StatePublished - Sep 1 2004

Keywords

  • Albumin variant
  • Bisalbuminemia
  • Chronic kidney disease
  • Dysproteinemia
  • Genetic trait
  • Renal disease

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)

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  • Cite this

    Ejaz, A. A., Krishna, M., Wasiluk, A., & Knight, J. D. (2004). Bisalbuminemia in chronic kidney disease. Clinical and Experimental Nephrology, 8(3), 270-273. https://doi.org/10.1007/s10157-004-0291-1