Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: Comparison with tacrine

Xiao Qiu Xiao, Nelson Tze Kin Lee, Paul R. Carlier, Yuan Ping Pang, Yi Fan Han

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

The present study investigates the effects of bis(7)-tacrine, a novel dimeric acetylcholinesterase inhibitor, on hydrogen peroxide(H2O2)-induced cell injury with comparison to the corresponding monomer, tacrine. Exposure of rat pheochromocytoma line PC12 cells to H2O2 induced significant cell damage. This reagent also caused redox desequilibrium as indicated by a decrease in activities of intracellular antioxidant enzymes such as glutathione peroxidase as well as catalase and an accumulation of malondialdehyde, a product of lipid peroxidation. Pretreatment of cells with bis(7)-tacrine or tacrine attenuated H2O2-induced cell toxicity, and bis(7)-tacrine demonstrated higher potency than tacrine in improving redox desequilibrium. These results suggest that bis(7)-tacrine and tacrine significantly protect against H2O2 insult, which might be beneficial for their potential usage in the prevention and treatment of Alzheimer's disease. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)197-200
Number of pages4
JournalNeuroscience Letters
Volume290
Issue number3
DOIs
StatePublished - Sep 1 2000

Keywords

  • Acetylcholinesterase inhibitor
  • Bis(7)-tacrine
  • Oxidative stress
  • PC12 cells
  • Tacrine

ASJC Scopus subject areas

  • Neuroscience(all)

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