Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: Comparison with tacrine

Xiao Qiu Xiao; Nelson Tze Kin Lee; Paul R. Carlier; Yuan Ping Pang; Yi Fan Han

doi:10.1016/S0304-3940(00)01357-4

Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: Comparison with tacrine

Xiao Qiu Xiao, Nelson Tze Kin Lee, Paul R. Carlier, Yuan Ping Pang, Yi Fan Han

Pharmacology

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

The present study investigates the effects of bis(7)-tacrine, a novel dimeric acetylcholinesterase inhibitor, on hydrogen peroxide(H₂O₂)-induced cell injury with comparison to the corresponding monomer, tacrine. Exposure of rat pheochromocytoma line PC12 cells to H₂O₂ induced significant cell damage. This reagent also caused redox desequilibrium as indicated by a decrease in activities of intracellular antioxidant enzymes such as glutathione peroxidase as well as catalase and an accumulation of malondialdehyde, a product of lipid peroxidation. Pretreatment of cells with bis(7)-tacrine or tacrine attenuated H₂O₂-induced cell toxicity, and bis(7)-tacrine demonstrated higher potency than tacrine in improving redox desequilibrium. These results suggest that bis(7)-tacrine and tacrine significantly protect against H₂O₂ insult, which might be beneficial for their potential usage in the prevention and treatment of Alzheimer's disease. (C) 2000 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	197-200
Number of pages	4
Journal	Neuroscience Letters
Volume	290
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(00)01357-4
State	Published - Sep 1 2000

Keywords

Acetylcholinesterase inhibitor
Bis(7)-tacrine
Oxidative stress
PC12 cells
Tacrine

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0304-3940(00)01357-4

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title = "Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: Comparison with tacrine",

abstract = "The present study investigates the effects of bis(7)-tacrine, a novel dimeric acetylcholinesterase inhibitor, on hydrogen peroxide(H2O2)-induced cell injury with comparison to the corresponding monomer, tacrine. Exposure of rat pheochromocytoma line PC12 cells to H2O2 induced significant cell damage. This reagent also caused redox desequilibrium as indicated by a decrease in activities of intracellular antioxidant enzymes such as glutathione peroxidase as well as catalase and an accumulation of malondialdehyde, a product of lipid peroxidation. Pretreatment of cells with bis(7)-tacrine or tacrine attenuated H2O2-induced cell toxicity, and bis(7)-tacrine demonstrated higher potency than tacrine in improving redox desequilibrium. These results suggest that bis(7)-tacrine and tacrine significantly protect against H2O2 insult, which might be beneficial for their potential usage in the prevention and treatment of Alzheimer's disease. (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "Acetylcholinesterase inhibitor, Bis(7)-tacrine, Oxidative stress, PC12 cells, Tacrine",

author = "Xiao, {Xiao Qiu} and Lee, {Nelson Tze Kin} and Carlier, {Paul R.} and Pang, {Yuan Ping} and Han, {Yi Fan}",

note = "Funding Information: This research is supported by grants from the Research Grant Council (HKUST 6156/97M and 6236 199M), Hong Kong, and the Biotechnology Research Institute, The Hong Kong University of Science & Technology, China. The authors are most grateful to Professor Xi Can Tang for valuable comments on the manuscript and Dr Rui Wang for technical aid.",

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AU - Carlier, Paul R.

AU - Pang, Yuan Ping

AU - Han, Yi Fan

N1 - Funding Information: This research is supported by grants from the Research Grant Council (HKUST 6156/97M and 6236 199M), Hong Kong, and the Biotechnology Research Institute, The Hong Kong University of Science & Technology, China. The authors are most grateful to Professor Xi Can Tang for valuable comments on the manuscript and Dr Rui Wang for technical aid.

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N2 - The present study investigates the effects of bis(7)-tacrine, a novel dimeric acetylcholinesterase inhibitor, on hydrogen peroxide(H2O2)-induced cell injury with comparison to the corresponding monomer, tacrine. Exposure of rat pheochromocytoma line PC12 cells to H2O2 induced significant cell damage. This reagent also caused redox desequilibrium as indicated by a decrease in activities of intracellular antioxidant enzymes such as glutathione peroxidase as well as catalase and an accumulation of malondialdehyde, a product of lipid peroxidation. Pretreatment of cells with bis(7)-tacrine or tacrine attenuated H2O2-induced cell toxicity, and bis(7)-tacrine demonstrated higher potency than tacrine in improving redox desequilibrium. These results suggest that bis(7)-tacrine and tacrine significantly protect against H2O2 insult, which might be beneficial for their potential usage in the prevention and treatment of Alzheimer's disease. (C) 2000 Elsevier Science Ireland Ltd.

AB - The present study investigates the effects of bis(7)-tacrine, a novel dimeric acetylcholinesterase inhibitor, on hydrogen peroxide(H2O2)-induced cell injury with comparison to the corresponding monomer, tacrine. Exposure of rat pheochromocytoma line PC12 cells to H2O2 induced significant cell damage. This reagent also caused redox desequilibrium as indicated by a decrease in activities of intracellular antioxidant enzymes such as glutathione peroxidase as well as catalase and an accumulation of malondialdehyde, a product of lipid peroxidation. Pretreatment of cells with bis(7)-tacrine or tacrine attenuated H2O2-induced cell toxicity, and bis(7)-tacrine demonstrated higher potency than tacrine in improving redox desequilibrium. These results suggest that bis(7)-tacrine and tacrine significantly protect against H2O2 insult, which might be beneficial for their potential usage in the prevention and treatment of Alzheimer's disease. (C) 2000 Elsevier Science Ireland Ltd.

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Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: Comparison with tacrine

Abstract

Keywords

ASJC Scopus subject areas

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