TY - JOUR
T1 - Biophysical modeling of sensitivity and positive accuracy of detecting episodic endocrine signals
AU - Urban, R. J.
AU - Johnson, M. L.
AU - Veldhuis, J. D.
PY - 1989
Y1 - 1989
N2 - To investigate the nature of false-negative and false-positive errors in endocrine signal detection, we used a multiparameter convolution procedure to create random hormone secretory bursts. We observed that 1) data containing high signal frequency, amplitude, and/or duration can be analyzed at less stringent peak-detection thresholds; 2) for any given secretory burst amplitude, increasing the peak-detection threshold enhances positive accuracy but decreases sensitivity; 3) increased sampling frequency improves sensitivity but requires more stringent peak-detection thresholds; and 4) increasing noise diminishes both sensitivity and positive accuracy. We conclude that secretory properties, peak-detector thresholds, investigator-specified sampling intensity, and experimental variance all significantly influence false-positive and false-negative errors associated with the enumeration of episodic endocrine pulse signals. The present observations should offer objective principles to aid in the rational design and analysis of neuroendocrine studies of pulsatile physiological phenomena.
AB - To investigate the nature of false-negative and false-positive errors in endocrine signal detection, we used a multiparameter convolution procedure to create random hormone secretory bursts. We observed that 1) data containing high signal frequency, amplitude, and/or duration can be analyzed at less stringent peak-detection thresholds; 2) for any given secretory burst amplitude, increasing the peak-detection threshold enhances positive accuracy but decreases sensitivity; 3) increased sampling frequency improves sensitivity but requires more stringent peak-detection thresholds; and 4) increasing noise diminishes both sensitivity and positive accuracy. We conclude that secretory properties, peak-detector thresholds, investigator-specified sampling intensity, and experimental variance all significantly influence false-positive and false-negative errors associated with the enumeration of episodic endocrine pulse signals. The present observations should offer objective principles to aid in the rational design and analysis of neuroendocrine studies of pulsatile physiological phenomena.
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M3 - Article
C2 - 2750899
AN - SCOPUS:0024391664
SN - 0002-9513
VL - 257
SP - 20/1
JO - American Journal of Physiology - Endocrinology and Metabolism
JF - American Journal of Physiology - Endocrinology and Metabolism
IS - 1
ER -