Biomaterials for Directed Differentiation

Xintong Wang, Angela L. Zachman, Simon Maltais, Hak Joon Sung

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Stem cells are immature cells that can potentially differentiate into multiple specialized cell types. The wonderful properties of stem cells, such as the ability to undergo both self-renewal and differentiation, make them a great cell source for regenerative medicine. The application of stem cells to tissue regeneration requires the development of suitable scaffolds to support their growth and differentiation of to the target cell type. The scaffolds should ideally be biocompatible, biodegradable, and mechanically and morphologically mimetic to the stem cell niche. Thus, both natural and synthetic biomaterials have been used for stem cell-based tissue engineering, with exciting successes. In this chapter, we discuss the progress of biomaterial-directed stem cell differentiation over the past 10 years, aiming to provide a comprehensive but concise review of the biomaterials chosen for application to regenerative medicine.

Original languageEnglish (US)
Title of host publicationChemical Biology in Regenerative Medicine
Subtitle of host publicationBridging Stem Cells and Future Therapies
Publisherwiley
Pages181-201
Number of pages21
ISBN (Electronic)9781118695746
ISBN (Print)9781118349595
DOIs
StatePublished - Jul 4 2014
Externally publishedYes

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Keywords

  • Biomaterial
  • Differentiation
  • Polymer
  • Regenerative medicine
  • Scaffold
  • Stem cell
  • Tissue engineering

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Wang, X., Zachman, A. L., Maltais, S., & Sung, H. J. (2014). Biomaterials for Directed Differentiation. In Chemical Biology in Regenerative Medicine: Bridging Stem Cells and Future Therapies (pp. 181-201). wiley. https://doi.org/10.1002/9781118695746.ch11