Biomarkers of Response to Preoperative Chemoradiation in Esophageal Cancers

Rajyalakshmi Luthra, Madan G. Luthra, Julie Izzo, Tsung Teh Wu, Enrique Lopez-Alvarez, Usha Malhotra, In Seon Choi, Li Zhang, Jaffer A. Ajani

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

To identify a panel of biomarkers that predicts response of esophageal cancers to preoperative chemoradiation, our group profiled the gene expression of pretreatment cancer biopsies from patients with esophageal cancer. Six (32%) of these patients had pathologic complete response. All cancers except one that achieved pathologic complete response (83%) clustered in one molecular type (type I), while cancers that achieved less than pathologic complete response with one exception clustered in another molecular type (type II). Activated NF-κB was significantly associated with aggressive pathology. These data indicate that expression analysis of a limited set of biomarkers selected from the list of genes that were differentially regulated between the two subtypes can increase predictive power, and suggest that esophageal cancer with activated NF-κB may result in poor treatment outcome.

Original languageEnglish (US)
Pages (from-to)2-5
Number of pages4
JournalSeminars in Oncology
Volume33
Issue numberSUPPL. 11
DOIs
StatePublished - Dec 2006
Externally publishedYes

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Esophageal Neoplasms
Biomarkers
Neoplasms
Pathology
Biopsy
Gene Expression
Genes

ASJC Scopus subject areas

  • Oncology

Cite this

Luthra, R., Luthra, M. G., Izzo, J., Wu, T. T., Lopez-Alvarez, E., Malhotra, U., ... Ajani, J. A. (2006). Biomarkers of Response to Preoperative Chemoradiation in Esophageal Cancers. Seminars in Oncology, 33(SUPPL. 11), 2-5. https://doi.org/10.1053/j.seminoncol.2006.10.004

Biomarkers of Response to Preoperative Chemoradiation in Esophageal Cancers. / Luthra, Rajyalakshmi; Luthra, Madan G.; Izzo, Julie; Wu, Tsung Teh; Lopez-Alvarez, Enrique; Malhotra, Usha; Choi, In Seon; Zhang, Li; Ajani, Jaffer A.

In: Seminars in Oncology, Vol. 33, No. SUPPL. 11, 12.2006, p. 2-5.

Research output: Contribution to journalArticle

Luthra, R, Luthra, MG, Izzo, J, Wu, TT, Lopez-Alvarez, E, Malhotra, U, Choi, IS, Zhang, L & Ajani, JA 2006, 'Biomarkers of Response to Preoperative Chemoradiation in Esophageal Cancers', Seminars in Oncology, vol. 33, no. SUPPL. 11, pp. 2-5. https://doi.org/10.1053/j.seminoncol.2006.10.004
Luthra R, Luthra MG, Izzo J, Wu TT, Lopez-Alvarez E, Malhotra U et al. Biomarkers of Response to Preoperative Chemoradiation in Esophageal Cancers. Seminars in Oncology. 2006 Dec;33(SUPPL. 11):2-5. https://doi.org/10.1053/j.seminoncol.2006.10.004
Luthra, Rajyalakshmi ; Luthra, Madan G. ; Izzo, Julie ; Wu, Tsung Teh ; Lopez-Alvarez, Enrique ; Malhotra, Usha ; Choi, In Seon ; Zhang, Li ; Ajani, Jaffer A. / Biomarkers of Response to Preoperative Chemoradiation in Esophageal Cancers. In: Seminars in Oncology. 2006 ; Vol. 33, No. SUPPL. 11. pp. 2-5.
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