TY - JOUR
T1 - Biomarkers of liver fibrosis
T2 - What lies beneath the receiver operating characteristic curve?
AU - Guha, Indra Neil
AU - Myers, Robert P.
AU - Patel, Keyur
AU - Talwalkar, Jayant A.
PY - 2011/10
Y1 - 2011/10
N2 - Noninvasive biomarkers of liver fibrosis represent an intense area of research with the goals of improving patient care, disease stratification, and aiding the development of future antifibrotic therapies. Despite the rapid progress in recent years, there remain questions about how diagnostic studies are designed, statistical methods to account for spectrum bias, clinically relevant thresholds of fibrosis that should be delineated, how diagnostics can be improved, and strengthening the reference test to judge emerging biomarkers. This review discusses the current methods to address these issues and where further progress is needed.
AB - Noninvasive biomarkers of liver fibrosis represent an intense area of research with the goals of improving patient care, disease stratification, and aiding the development of future antifibrotic therapies. Despite the rapid progress in recent years, there remain questions about how diagnostic studies are designed, statistical methods to account for spectrum bias, clinically relevant thresholds of fibrosis that should be delineated, how diagnostics can be improved, and strengthening the reference test to judge emerging biomarkers. This review discusses the current methods to address these issues and where further progress is needed.
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U2 - 10.1002/hep.24515
DO - 10.1002/hep.24515
M3 - Review article
C2 - 21725995
AN - SCOPUS:81155162421
SN - 0270-9139
VL - 54
SP - 1454
EP - 1462
JO - Hepatology
JF - Hepatology
IS - 4
ER -