Biomarkers of cardiovascular injury and stress are associated with increased frequency of ventricular ectopy

A population-based study

Julia Brox Skranes, Gunnar Einvik, Silje Kjeka Namtvedt, Anna Randby, Harald Hrubos-Strøm, Jon Brynildsen, Tor Arne Hagve, Virend Somers, Helge Røsjø, Torbjørn Omland

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Asymptomatic ventricular arrhythmias are common and associated with increased risk of cardiovascular mortality. Cardiac troponins, natriuretic peptides and C-reactive protein (CRP) are also predictive of adverse cardiovascular events in the general population, but limited information is available on the relationship between these biomarkers and ventricular ectopy in a community-based population. The objectives were to evaluate the associations between ventricular ectopic activity and N-terminal pro-B-type natriuretic peptide (NT-proBNP), high sensitivity-troponin I (hs-TnI) and hs-CRP in a community-based setting. Methods: We performed a 24h Holter-recording and blood sampling in 498 subjects. Premature ventricular complexes (PVC) were classified as frequent at >5/h and the presence of any bigeminy, trigeminy or non-sustained ventricular tachycardia were classified as complex ventricular ectopy. The associations between biomarkers and ventricular arrhythmias were investigated by univariate and multivariate logistic regression analyses. Results: Frequent PVC's and complex ventricular ectopy were detected in 46 (9%) and 47 (9%) participants respectively, and were associated with significantly (p<0.001) higher concentrations of NT-proBNP and hs-TnI. The association between NT-proBNP and both frequent PVC's (p=0.020) and complex ventricular ectopy (p=0.001) remained significant after adjusting for conventional risk markers in multivariate analyses. Conclusion: Increased level of NT-proBNP was independently associated with ventricular ectopy, whereas no independent association was observed between hs-TnI and hs-CRP levels and ventricular ectopy in this community-based sample.

Original languageEnglish (US)
Article number233
JournalBMC Cardiovascular Disorders
Volume16
Issue number1
DOIs
StatePublished - Nov 22 2016

Fingerprint

Brain Natriuretic Peptide
Biomarkers
C-Reactive Protein
Troponin I
Wounds and Injuries
Polyvinyl Chloride
Population
Cardiac Arrhythmias
Natriuretic Peptides
Troponin
Ventricular Premature Complexes
Ventricular Tachycardia
Multivariate Analysis
Logistic Models
Regression Analysis
Mortality

Keywords

  • Arrhythmias
  • C-reactive protein
  • NT-proBNP
  • Troponin I

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Biomarkers of cardiovascular injury and stress are associated with increased frequency of ventricular ectopy : A population-based study. / Skranes, Julia Brox; Einvik, Gunnar; Namtvedt, Silje Kjeka; Randby, Anna; Hrubos-Strøm, Harald; Brynildsen, Jon; Hagve, Tor Arne; Somers, Virend; Røsjø, Helge; Omland, Torbjørn.

In: BMC Cardiovascular Disorders, Vol. 16, No. 1, 233, 22.11.2016.

Research output: Contribution to journalArticle

Skranes, JB, Einvik, G, Namtvedt, SK, Randby, A, Hrubos-Strøm, H, Brynildsen, J, Hagve, TA, Somers, V, Røsjø, H & Omland, T 2016, 'Biomarkers of cardiovascular injury and stress are associated with increased frequency of ventricular ectopy: A population-based study', BMC Cardiovascular Disorders, vol. 16, no. 1, 233. https://doi.org/10.1186/s12872-016-0407-z
Skranes, Julia Brox ; Einvik, Gunnar ; Namtvedt, Silje Kjeka ; Randby, Anna ; Hrubos-Strøm, Harald ; Brynildsen, Jon ; Hagve, Tor Arne ; Somers, Virend ; Røsjø, Helge ; Omland, Torbjørn. / Biomarkers of cardiovascular injury and stress are associated with increased frequency of ventricular ectopy : A population-based study. In: BMC Cardiovascular Disorders. 2016 ; Vol. 16, No. 1.
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T2 - A population-based study

AU - Skranes, Julia Brox

AU - Einvik, Gunnar

AU - Namtvedt, Silje Kjeka

AU - Randby, Anna

AU - Hrubos-Strøm, Harald

AU - Brynildsen, Jon

AU - Hagve, Tor Arne

AU - Somers, Virend

AU - Røsjø, Helge

AU - Omland, Torbjørn

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Y1 - 2016/11/22

N2 - Background: Asymptomatic ventricular arrhythmias are common and associated with increased risk of cardiovascular mortality. Cardiac troponins, natriuretic peptides and C-reactive protein (CRP) are also predictive of adverse cardiovascular events in the general population, but limited information is available on the relationship between these biomarkers and ventricular ectopy in a community-based population. The objectives were to evaluate the associations between ventricular ectopic activity and N-terminal pro-B-type natriuretic peptide (NT-proBNP), high sensitivity-troponin I (hs-TnI) and hs-CRP in a community-based setting. Methods: We performed a 24h Holter-recording and blood sampling in 498 subjects. Premature ventricular complexes (PVC) were classified as frequent at >5/h and the presence of any bigeminy, trigeminy or non-sustained ventricular tachycardia were classified as complex ventricular ectopy. The associations between biomarkers and ventricular arrhythmias were investigated by univariate and multivariate logistic regression analyses. Results: Frequent PVC's and complex ventricular ectopy were detected in 46 (9%) and 47 (9%) participants respectively, and were associated with significantly (p<0.001) higher concentrations of NT-proBNP and hs-TnI. The association between NT-proBNP and both frequent PVC's (p=0.020) and complex ventricular ectopy (p=0.001) remained significant after adjusting for conventional risk markers in multivariate analyses. Conclusion: Increased level of NT-proBNP was independently associated with ventricular ectopy, whereas no independent association was observed between hs-TnI and hs-CRP levels and ventricular ectopy in this community-based sample.

AB - Background: Asymptomatic ventricular arrhythmias are common and associated with increased risk of cardiovascular mortality. Cardiac troponins, natriuretic peptides and C-reactive protein (CRP) are also predictive of adverse cardiovascular events in the general population, but limited information is available on the relationship between these biomarkers and ventricular ectopy in a community-based population. The objectives were to evaluate the associations between ventricular ectopic activity and N-terminal pro-B-type natriuretic peptide (NT-proBNP), high sensitivity-troponin I (hs-TnI) and hs-CRP in a community-based setting. Methods: We performed a 24h Holter-recording and blood sampling in 498 subjects. Premature ventricular complexes (PVC) were classified as frequent at >5/h and the presence of any bigeminy, trigeminy or non-sustained ventricular tachycardia were classified as complex ventricular ectopy. The associations between biomarkers and ventricular arrhythmias were investigated by univariate and multivariate logistic regression analyses. Results: Frequent PVC's and complex ventricular ectopy were detected in 46 (9%) and 47 (9%) participants respectively, and were associated with significantly (p<0.001) higher concentrations of NT-proBNP and hs-TnI. The association between NT-proBNP and both frequent PVC's (p=0.020) and complex ventricular ectopy (p=0.001) remained significant after adjusting for conventional risk markers in multivariate analyses. Conclusion: Increased level of NT-proBNP was independently associated with ventricular ectopy, whereas no independent association was observed between hs-TnI and hs-CRP levels and ventricular ectopy in this community-based sample.

KW - Arrhythmias

KW - C-reactive protein

KW - NT-proBNP

KW - Troponin I

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