Biomarkers for prognosis in pancreatic neuroendocrine tumors

Mojun Zhu; Karl R. Sorenson; Rebecca Liu; Bonnie E. Gould Rothberg; Thorvardur R. Halfdanarson

doi:10.1530/ERC-21-0075

Biomarkers for prognosis in pancreatic neuroendocrine tumors

Mojun Zhu, Karl R. Sorenson, Rebecca Liu, Bonnie E. Gould Rothberg, Thorvardur R. Halfdanarson

Medical Oncology

Research output: Contribution to journal › Article › peer-review

Abstract

Pancreatic neuroendocrine tumors (PNETs) encompass a diverse group of malignancies marked by histological heterogeneity and highly variable clinical outcomes. We performed a systematic review on potential prognostic biomarkers in PNETs by searching the PubMed database. A total of 472 manuscripts were reviewed in detail, of which 52 multivariate studies met the inclusion criteria proposed by the Reporting Recommendations for Tumor Marker Prognostic Studies. These altogether analyzed 53 unique targets, and 36 of them were statistically associated with survival.

Original language	English (US)
Pages (from-to)	773-782
Number of pages	10
Journal	Endocrine-Related Cancer
Volume	28
Issue number	12
DOIs	https://doi.org/10.1530/ERC-21-0075
State	Published - Dec 2021

Keywords

biomarker
neuroendocrine
pancreatic
prognosis

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Oncology
Endocrinology
Cancer Research

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10.1530/ERC-21-0075

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title = "Biomarkers for prognosis in pancreatic neuroendocrine tumors",

abstract = "Pancreatic neuroendocrine tumors (PNETs) encompass a diverse group of malignancies marked by histological heterogeneity and highly variable clinical outcomes. We performed a systematic review on potential prognostic biomarkers in PNETs by searching the PubMed database. A total of 472 manuscripts were reviewed in detail, of which 52 multivariate studies met the inclusion criteria proposed by the Reporting Recommendations for Tumor Marker Prognostic Studies. These altogether analyzed 53 unique targets, and 36 of them were statistically associated with survival.",

keywords = "biomarker, neuroendocrine, pancreatic, prognosis",

author = "Mojun Zhu and Sorenson, {Karl R.} and Rebecca Liu and {Gould Rothberg}, {Bonnie E.} and Halfdanarson, {Thorvardur R.}",

note = "Publisher Copyright: {\textcopyright} 2021 Society for Endocrinology Published by Bioscientifica Ltd.",

year = "2021",

month = dec,

doi = "10.1530/ERC-21-0075",

language = "English (US)",

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T1 - Biomarkers for prognosis in pancreatic neuroendocrine tumors

AU - Zhu, Mojun

AU - Sorenson, Karl R.

AU - Liu, Rebecca

AU - Gould Rothberg, Bonnie E.

AU - Halfdanarson, Thorvardur R.

PY - 2021/12

Y1 - 2021/12

N2 - Pancreatic neuroendocrine tumors (PNETs) encompass a diverse group of malignancies marked by histological heterogeneity and highly variable clinical outcomes. We performed a systematic review on potential prognostic biomarkers in PNETs by searching the PubMed database. A total of 472 manuscripts were reviewed in detail, of which 52 multivariate studies met the inclusion criteria proposed by the Reporting Recommendations for Tumor Marker Prognostic Studies. These altogether analyzed 53 unique targets, and 36 of them were statistically associated with survival.

AB - Pancreatic neuroendocrine tumors (PNETs) encompass a diverse group of malignancies marked by histological heterogeneity and highly variable clinical outcomes. We performed a systematic review on potential prognostic biomarkers in PNETs by searching the PubMed database. A total of 472 manuscripts were reviewed in detail, of which 52 multivariate studies met the inclusion criteria proposed by the Reporting Recommendations for Tumor Marker Prognostic Studies. These altogether analyzed 53 unique targets, and 36 of them were statistically associated with survival.

KW - biomarker

KW - neuroendocrine

KW - pancreatic

KW - prognosis

UR - http://www.scopus.com/inward/record.url?scp=85119458013&partnerID=8YFLogxK

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EP - 782

JO - Endocrine-Related Cancer

JF - Endocrine-Related Cancer

IS - 12

ER -

Biomarkers for prognosis in pancreatic neuroendocrine tumors

Abstract

Keywords

ASJC Scopus subject areas

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