Biomarker identification by knowledge-driven multi-level ICA and motif analysis

Li Chen, Chen Wang, Ie Ming Shih, Tian Li Wang, Zhen Zhang, Yue Wang, Robert Clarke, Eric Hoffman, Jianhua Xuan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Many statistical methods often fail to identify biologically meaningful biomarkers related to a specific disease under study from expression data alone. In this paper, we develop a novel strategy, namely knowledge-driven multi-level independent component analysis (ICA), to infer regulatory signals and identify biologically relevant biomarkers from microarray data. Specifically, based on multi-level clustering results and partial prior knowledge, we apply ICA to find stable disease specific linear regulatory modes and then extract associated biomarker genes. A statistical test is designed to evaluate the significance of transcription factor enrichment for extracted gene set based on motif information. The experimental results on an Rsf-1 induced microarray data set show that our knowledgedriven method can extract more biologically meaningful biomarkers with significant enrichment of transcription factors related to ovarian cancer compared to other gene selection methods with/without prior knowledge.

Original languageEnglish (US)
Title of host publicationProceedings - 6th International Conference on Machine Learning and Applications, ICMLA 2007
Pages560-566
Number of pages7
DOIs
StatePublished - Dec 1 2007
Event6th International Conference on Machine Learning and Applications, ICMLA 2007 - Cincinnati, OH, United States
Duration: Dec 13 2007Dec 15 2007

Publication series

NameProceedings - 6th International Conference on Machine Learning and Applications, ICMLA 2007

Other

Other6th International Conference on Machine Learning and Applications, ICMLA 2007
CountryUnited States
CityCincinnati, OH
Period12/13/0712/15/07

ASJC Scopus subject areas

  • Computer Science Applications
  • Human-Computer Interaction
  • Control and Systems Engineering

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    Chen, L., Wang, C., Shih, I. M., Wang, T. L., Zhang, Z., Wang, Y., Clarke, R., Hoffman, E., & Xuan, J. (2007). Biomarker identification by knowledge-driven multi-level ICA and motif analysis. In Proceedings - 6th International Conference on Machine Learning and Applications, ICMLA 2007 (pp. 560-566). [4457289] (Proceedings - 6th International Conference on Machine Learning and Applications, ICMLA 2007). https://doi.org/10.1109/ICMLA.2007.24