Biology of the Natriuretic Peptides

Abelardo Martinez-Rumayor, A. Mark Richards, John C Jr. Burnett, James L. Januzzi

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

The biology of the natriuretic peptide (NP) system is complex, yet highly phylogenetically preserved. It regulates salt and water handling, promotes vasodilatation, and exerts favorable effects on the heart in the context of processes such as heart failure. Prior assumptions about the production of B-type NP (BNP) and its amino-terminal precursor fragment (NT-proBNP) have recently been refuted. It is now recognized that rather than a 1:1 secretion of these 2 NPs, a mixture of cleaved and uncleaved NPs is released by the cardiomyocyte. It is also recognized that BNP is rapidly modified into a mixture of various fragments. Commercial assays for the detection of BNP and NT-proBNP measure a mixture of cleaved and uncleaved NPs as well as varying amounts of degraded BNP. BNP and NT-proBNP are cleared differentially: BNP is actively removed from the bloodstream and also has passive clearance mechanisms, including renal clearance; NT-proBNP is cleared more passively by organs with high rates of blood flow, including the kidney.

Original languageEnglish (US)
JournalAmerican Journal of Cardiology
Volume101
Issue number3 SUPPL.
DOIs
StatePublished - Feb 4 2008

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Natriuretic Peptides
Kidney
Brain Natriuretic Peptide
Cardiac Myocytes
Vasodilation
Heart Failure
Salts
pro-brain natriuretic peptide (1-76)
Water

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Biology of the Natriuretic Peptides. / Martinez-Rumayor, Abelardo; Richards, A. Mark; Burnett, John C Jr.; Januzzi, James L.

In: American Journal of Cardiology, Vol. 101, No. 3 SUPPL., 04.02.2008.

Research output: Contribution to journalArticle

Martinez-Rumayor, A, Richards, AM, Burnett, JCJ & Januzzi, JL 2008, 'Biology of the Natriuretic Peptides', American Journal of Cardiology, vol. 101, no. 3 SUPPL.. https://doi.org/10.1016/j.amjcard.2007.11.012
Martinez-Rumayor, Abelardo ; Richards, A. Mark ; Burnett, John C Jr. ; Januzzi, James L. / Biology of the Natriuretic Peptides. In: American Journal of Cardiology. 2008 ; Vol. 101, No. 3 SUPPL.
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