TY - JOUR
T1 - Biology and pathobiology of lipid droplets and their potential role in the protection of the organ of Corti
AU - Urrutia, Raul A.
AU - Kalinec, Federico
N1 - Funding Information:
The authors thank Yi Guo, Yin Peng, Gwen Lomberk, Gilda Kalinec and Pru Thein for critically reading the manuscript. FK is supported by NIH Grants DC010146 and DC 010397 and UCLA's Department of Head and Neck Surgery funds; RU is funded by NIH grant DK52913 , the Mayo Clinic Center for Cell Signaling ( P30DK084567 ), SPORE P50 CA102701 , and Mayo Foundation funds. The content of this work is solely the responsibility of the authors and does not necessarily represent the off i cial views of these Institutions. The authors declare no existing or potential conflict of interest.
Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - The current review article seeks to extend our understanding on the role of lipid droplets within the organ of Corti. In addition to presenting an overview of the current information about the origin, structure and function of lipid droplets we draw inferences from the collective body of knowledge about this cellular organelle to build a conceptual framework to better understanding their role in auditory function. This conceptual model considers that lipid droplets play a significant role in the synthesis, storage, and release of lipids and proteins for energetic use and/or modulating cell signaling pathways. We describe the role and mechanism by which LD play a role in human diseases, and we also review emerging data from our laboratory revealing the potential role of lipid droplets from Hensen cells in the auditory organ. We suggest that lipid droplets might help to develop rapidly and efficiently the resolution phase of inflammatory responses in the mammalian cochlea, preventing inflammatory damage of the delicate inner ear structures and, consequently, sensorineural hearing loss. This article is part of a Special Issue entitled <IEB Kyoto>.
AB - The current review article seeks to extend our understanding on the role of lipid droplets within the organ of Corti. In addition to presenting an overview of the current information about the origin, structure and function of lipid droplets we draw inferences from the collective body of knowledge about this cellular organelle to build a conceptual framework to better understanding their role in auditory function. This conceptual model considers that lipid droplets play a significant role in the synthesis, storage, and release of lipids and proteins for energetic use and/or modulating cell signaling pathways. We describe the role and mechanism by which LD play a role in human diseases, and we also review emerging data from our laboratory revealing the potential role of lipid droplets from Hensen cells in the auditory organ. We suggest that lipid droplets might help to develop rapidly and efficiently the resolution phase of inflammatory responses in the mammalian cochlea, preventing inflammatory damage of the delicate inner ear structures and, consequently, sensorineural hearing loss. This article is part of a Special Issue entitled <IEB Kyoto>.
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U2 - 10.1016/j.heares.2015.04.015
DO - 10.1016/j.heares.2015.04.015
M3 - Review article
C2 - 25987503
AN - SCOPUS:84949097730
SN - 0378-5955
VL - 330
SP - 26
EP - 38
JO - Hearing Research
JF - Hearing Research
ER -