Biological role for the endothelin-A receptor in aortic cross-clamping

Andrew J. Stingo, Alfredo L. Clavell, Lawrence L. Aarhus, John C. Burnett

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The current study was undertaken to define a biological role for the endothelin-A receptor in a clinically relevant model of altered systemic and renal function produced by suprarenal aortic cross-clamping. This model is associated with profound systemic and renal vasoconstriction, acute renal failure, and a significant increase in circulating endothelin. Studies were performed in three groups of anesthetized mongrel dogs. Group 1 (n=5) underwent aortic cross-clamping for 1 hour, group 2 (n=5) underwent aortic cross-clamping for 1 hour in the presence of BQ-123, a specific antagonist of the endothelin-A receptor; group 3 (n=4) received BQ-123 alone. The marked systemic and renal vasoconstriction associated with aortic cross-clamping in group 1 was markedly attenuated in group 2 in the presence of BQ-123. Unlike the vasoconstrictor response, BQ-123 did not attenuate the decrease in glomerular filtration rate associated with this model. Under unstimulated conditions in group 3, BQ-123 had no actions on systemic or renal hemodynamics. In conclusion, the current study demonstrates that the systemic and renal vasoconstriction associated with aortic cross-clamping are in part mediated through the interaction of endothelin and the endothelin-A receptor. This study demonstrates the functional importance of increased endogenous endothelin in the regulation of vascular tone in this pathophysiological state.

Original languageEnglish (US)
Pages (from-to)62-66
Number of pages5
JournalHypertension
Volume22
Issue number1
DOIs
StatePublished - Jul 1993

Keywords

  • Endothelins
  • Receptors, endothelin
  • Renal failure, acute
  • Vascular resistance

ASJC Scopus subject areas

  • Internal Medicine

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