Biological implications and regulatory mechanisms of long-range chromosomal interactions

Zong Wei, David Huang, Fan Gao, Wen Hsuan Chang, Woojin An, Gerhard A. Coetzee, Kai Wang, Wange Lu

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Development of high-throughput sequencing-based methods has enabled us to examine nuclear architecture at unprecedented resolution, allowing further examination of the function of long-range chromosomal interactions. Here, we review methods used to investigate novel long-range chromosomal interactions and genome-wide organization of chromatin. We further discuss transcriptional activation and silencing in relation to organization and positioning of gene loci and regulation of chromatin organization through protein complexes and noncoding RNAs.

Original languageEnglish (US)
Pages (from-to)22369-22377
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number31
DOIs
StatePublished - Aug 2 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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