TY - CHAP
T1 - Biological horizons for targeting brain malignancy
AU - Hughes, Samuel A.
AU - Achanta, Pragathi
AU - Ho, Allen L.
AU - Duenas, Vincent J.
AU - Quinones-Hinojosa, Alfredo
PY - 2010
Y1 - 2010
N2 - Though currently available clinical treatments and therapies have clearly extended the survival of patients with brain tumors, many of these advances are short lived, particularly with respect to high grade gliomas such as glioblastoma multiforme. The missing link to an efficacious treatment of high grade gliomas is a more complete understanding of the basic molecular and cellular origin of brain tumors. However, new discoveries of stem cell and developmental neurobiology have now borne the cancer stem cell hypothesis, drawing off of intriguing similarities between benign and malignant cells within the central nervous system. Investigation of cancer stem cell hypothesis and brain tumor propagation is the current frontier of stem cell and cancer biology. Neurosurgery is also watching closely this promising new area of focus. "Molecular neurosurgery", glioma treatments involving biologics using neural stem cells to target the cancer at the level of individual migratory cell, is a rapidly evolving field. This coming progression of applied cancer stem cell research, coupled with current modalities, promises more comprehensive brain cancer interventions.
AB - Though currently available clinical treatments and therapies have clearly extended the survival of patients with brain tumors, many of these advances are short lived, particularly with respect to high grade gliomas such as glioblastoma multiforme. The missing link to an efficacious treatment of high grade gliomas is a more complete understanding of the basic molecular and cellular origin of brain tumors. However, new discoveries of stem cell and developmental neurobiology have now borne the cancer stem cell hypothesis, drawing off of intriguing similarities between benign and malignant cells within the central nervous system. Investigation of cancer stem cell hypothesis and brain tumor propagation is the current frontier of stem cell and cancer biology. Neurosurgery is also watching closely this promising new area of focus. "Molecular neurosurgery", glioma treatments involving biologics using neural stem cells to target the cancer at the level of individual migratory cell, is a rapidly evolving field. This coming progression of applied cancer stem cell research, coupled with current modalities, promises more comprehensive brain cancer interventions.
UR - http://www.scopus.com/inward/record.url?scp=77952995764&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952995764&partnerID=8YFLogxK
U2 - 10.1007/978-1-4419-5819-8_8
DO - 10.1007/978-1-4419-5819-8_8
M3 - Chapter
C2 - 20455498
AN - SCOPUS:77952995764
SN - 9781441958181
T3 - Advances in Experimental Medicine and Biology
SP - 93
EP - 104
BT - Frontiers in Brain Repair
A2 - Jandial, Rahul
ER -