Biological Cardiac Tissue Effects of High-Energy Heavy Ions – Investigation for Myocardial Ablation

Felicitas Rapp, Palma Simoniello, Julia Wiedemann, Karola Bahrami, Valeria Grünebaum, Svetlana Ktitareva, Marco Durante, P. Lugenbiel, D. Thomas, H. Immo Lehmann, Douglas L Packer, Christian Graeff, Claudia Fournier

Research output: Contribution to journalArticle

Abstract

Noninvasive X-ray stereotactic treatment is considered a promising alternative to catheter ablation in patients affected by severe heart arrhythmia. High-energy heavy ions can deliver high radiation doses in small targets with reduced damage to the normal tissue compared to conventional X-rays. For this reason, charged particle therapy, widely used in oncology, can be a powerful tool for radiosurgery in cardiac diseases. We have recently performed a feasibility study in a swine model using high doses of high-energy C-ions to target specific cardiac structures. Interruption of cardiac conduction was observed in some animals. Here we report the biological effects measured in the pig heart tissue of the same animals six months after the treatment. Immunohistological analysis of the target tissue showed (1.) long-lasting vascular damage, i.e. persistent hemorrhage, loss of microvessels, and occurrence of siderophages, (2.) fibrosis and (3.) loss of polarity of targeted cardiomyocytes and wavy fibers with vacuolization. We conclude that the observed physiological changes in heart function are produced by radiation-induced fibrosis and cardiomyocyte functional inactivation. No effects were observed in the normal tissue traversed by the particle beam, suggesting that charged particles have the potential to produce ablation of specific heart targets with minimal side effects.

Original languageEnglish (US)
Article number5000
JournalScientific reports
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2019

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Heavy Ions
Cardiac Myocytes
Swine
X-Rays
Radiation Pneumonitis
Catheter Ablation
Radiosurgery
Feasibility Studies
Microvessels
Blood Vessels
Cardiac Arrhythmias
Heart Diseases
Fibrosis
Therapeutics
Ions
Radiation
Hemorrhage

ASJC Scopus subject areas

  • General

Cite this

Rapp, F., Simoniello, P., Wiedemann, J., Bahrami, K., Grünebaum, V., Ktitareva, S., ... Fournier, C. (2019). Biological Cardiac Tissue Effects of High-Energy Heavy Ions – Investigation for Myocardial Ablation. Scientific reports, 9(1), [5000]. https://doi.org/10.1038/s41598-019-41314-x

Biological Cardiac Tissue Effects of High-Energy Heavy Ions – Investigation for Myocardial Ablation. / Rapp, Felicitas; Simoniello, Palma; Wiedemann, Julia; Bahrami, Karola; Grünebaum, Valeria; Ktitareva, Svetlana; Durante, Marco; Lugenbiel, P.; Thomas, D.; Lehmann, H. Immo; Packer, Douglas L; Graeff, Christian; Fournier, Claudia.

In: Scientific reports, Vol. 9, No. 1, 5000, 01.12.2019.

Research output: Contribution to journalArticle

Rapp, F, Simoniello, P, Wiedemann, J, Bahrami, K, Grünebaum, V, Ktitareva, S, Durante, M, Lugenbiel, P, Thomas, D, Lehmann, HI, Packer, DL, Graeff, C & Fournier, C 2019, 'Biological Cardiac Tissue Effects of High-Energy Heavy Ions – Investigation for Myocardial Ablation', Scientific reports, vol. 9, no. 1, 5000. https://doi.org/10.1038/s41598-019-41314-x
Rapp, Felicitas ; Simoniello, Palma ; Wiedemann, Julia ; Bahrami, Karola ; Grünebaum, Valeria ; Ktitareva, Svetlana ; Durante, Marco ; Lugenbiel, P. ; Thomas, D. ; Lehmann, H. Immo ; Packer, Douglas L ; Graeff, Christian ; Fournier, Claudia. / Biological Cardiac Tissue Effects of High-Energy Heavy Ions – Investigation for Myocardial Ablation. In: Scientific reports. 2019 ; Vol. 9, No. 1.
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