TY - JOUR
T1 - Biological basis of depression and therapeutic relevance
AU - Richelson, E.
N1 - Copyright:
Copyright 2004 Elsevier B.V., All rights reserved.
PY - 1991
Y1 - 1991
N2 - Before the advent of the pharmacologic treatment of depression, there were theories about the biological basis of affective disorders. However, today's theories are derived largely from known pharmacologic effects of antidepressants. These effects, derived from neurochemical studies with laboratory animals, have implicated catecholamines and serotonin in depression. Although most antidepressant drugs in use today have been available for decades, their mechanism of action in treating depression has not been established. In addition, theories about the biological causes of depression have not been proven. Nevertheless, the rich pharmacology for antidepressant drugs involving blockade of neuronal uptake systems for some biogenic amines and blockade of many receptors for neurotransmitters can explain some of their adverse effects and certain interactions with other drugs.
AB - Before the advent of the pharmacologic treatment of depression, there were theories about the biological basis of affective disorders. However, today's theories are derived largely from known pharmacologic effects of antidepressants. These effects, derived from neurochemical studies with laboratory animals, have implicated catecholamines and serotonin in depression. Although most antidepressant drugs in use today have been available for decades, their mechanism of action in treating depression has not been established. In addition, theories about the biological causes of depression have not been proven. Nevertheless, the rich pharmacology for antidepressant drugs involving blockade of neuronal uptake systems for some biogenic amines and blockade of many receptors for neurotransmitters can explain some of their adverse effects and certain interactions with other drugs.
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M3 - Article
C2 - 1646793
AN - SCOPUS:0025912653
VL - 52
SP - 4
EP - 10
JO - Journal of Clinical Psychiatry
JF - Journal of Clinical Psychiatry
SN - 0160-6689
IS - 6 SUPPL.
ER -