Biological actions of brain natriuretic peptide in thoracic inferior vena caval constriction

A. L. Clavell, A. J. Stingo, L. L. Aarhus, J. C. Burnett

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Brain natriuretic peptide (BNP) shares structural and functional similarities to atrial natriuretic peptide (ANP). Although BNP and ANP interact with the same biologically active guanylate cyclase-coupled receptor, recent reports conflict with regard to the biological actions of exogenous BNP in sodium-retaining and edematous states. We studied the biological actions of BNP in normal dogs (n = 5) and sodium-avid dogs with chronic thoracic inferior vena caval constriction (TIVCC) (n = 6). In normal dogs BNP increased glomerular filtration rate, renal blood flow, and urinary sodium excretion and decreased proximal and distal fractional reabsorption of sodium with activation of urinary guanosine 3',5'-cyclic monophosphate (cGMP). These renal actions occurred in association with marked hypotensive actions and activation of systemic cGMP. In TIVCC, a state characterized by chronic reductions of cardiac output, avid sodium retention, edema, and activation of the renin-angiotensin-aldosterone system (RAAS), the renal actions of BNP were absent in association with marked attenuation of the urinary cGMP response. In contrast, an enhanced hypotensive response with preserved activation of systemic cGMP was observed. In neither normal dogs nor TIVCC dogs did BNP inhibit the RAAS. These studies report that BNP is a potent vasoactive and natriuretic peptide with potent proximal and distal tubular actions in normal dogs. These studies also demonstrate that in TIVCC, a model of low cardiac output and congestive failure that results in marked sodium retention with edema in which there is activation of the RAAS, the renal actions of BNP are attenuated while the vasoactive actions are enhanced.

Original languageEnglish (US)
Pages (from-to)R1416-R1422
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number6 34-6
StatePublished - 1993


  • guanosine 3',5'-cyclic monophosphate
  • natriuretic peptides
  • renal sodium excretion
  • thoracic inferior vena caval constriction

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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