Biologic therapies for non-hodgkin lymphoma and hodgkin disease

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) are B-cell malignancies that together account for an estimated 75,000 new cases in the United States annually. Many patients with these diseases are successfully treated with cytotoxic therapy; however, the addition of biologic therapy in the form of the anti-CD20 antibody rituximab has significantly improved the outcome of patients, particularly those with B-cell NHL. The success of this agent has led to the development of multiple other monoclonal antibodies directed at targets on lymphoma cells and these therapies are now in clinical trials to determine their utility in the treatment of patients with NHL and HL.

Original languageEnglish (US)
Title of host publicationEmerging Protein Biotherapeutics
PublisherCRC Press
Pages223-245
Number of pages23
ISBN (Electronic)9781420063219
ISBN (Print)1420063200, 9781420063202
StatePublished - Jan 1 2009

Keywords

  • Hodgkin’s disease
  • Monoclonal antibody
  • Non-hodgkin lymphoma

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Ansell, S. M. (2009). Biologic therapies for non-hodgkin lymphoma and hodgkin disease. In Emerging Protein Biotherapeutics (pp. 223-245). CRC Press.