Biologic nanoparticles and vascular disease

Maria K. Schwartz; John C. Lieske; Virginia M. Miller

doi:10.1007/978-1-4419-7222-4_24

Biologic nanoparticles and vascular disease

Maria K. Schwartz, John C. Lieske, Virginia M. Miller

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Sustained or repeating chronic infections have been linked to arterial calcification. Biologic nanoparticles (NPs) that propagate in culture have been isolated from calcified soft tissues. When inoculated into experimental animals, NPs appear to exacerbate the arterial response to injury, up to and including medial discontinuity and vascular occlusion. These NPs may be re-assembled proteins and microvesicles derived from mammalian cells and/or microorganisms.

Original language	English (US)
Title of host publication	Atherosclerosis Disease Management
Publisher	Springer New York
Pages	749-763
Number of pages	15
ISBN (Print)	9781441972217
DOIs	https://doi.org/10.1007/978-1-4419-7222-4_24
State	Published - 2011

Keywords

Arterial calcification
Calcium
Hydroxyapatite
Infection
Inflammation

ASJC Scopus subject areas

General Medicine

Access to Document

10.1007/978-1-4419-7222-4_24

Cite this

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keywords = "Arterial calcification, Calcium, Hydroxyapatite, Infection, Inflammation",

author = "Schwartz, {Maria K.} and Lieske, {John C.} and Miller, {Virginia M.}",

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AU - Lieske, John C.

AU - Miller, Virginia M.

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AB - Sustained or repeating chronic infections have been linked to arterial calcification. Biologic nanoparticles (NPs) that propagate in culture have been isolated from calcified soft tissues. When inoculated into experimental animals, NPs appear to exacerbate the arterial response to injury, up to and including medial discontinuity and vascular occlusion. These NPs may be re-assembled proteins and microvesicles derived from mammalian cells and/or microorganisms.

KW - Arterial calcification

KW - Calcium

KW - Hydroxyapatite

KW - Infection

KW - Inflammation

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PB - Springer New York

ER -

Biologic nanoparticles and vascular disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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