Biologic nanoparticles and vascular disease

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Sustained or repeating chronic infections have been linked to arterial calcification. Biologic nanoparticles (NPs) that propagate in culture have been isolated from calcified soft tissues. When inoculated into experimental animals, NPs appear to exacerbate the arterial response to injury, up to and including medial discontinuity and vascular occlusion. These NPs may be re-assembled proteins and microvesicles derived from mammalian cells and/or microorganisms.

Original languageEnglish (US)
Title of host publicationAtherosclerosis Disease Management
PublisherSpringer New York
Pages749-763
Number of pages15
ISBN (Print)9781441972217
DOIs
StatePublished - Dec 1 2011

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Keywords

  • Arterial calcification
  • Calcium
  • Hydroxyapatite
  • Infection
  • Inflammation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Schwartz, M. K., Lieske, J. C., & Miller, V. M. (2011). Biologic nanoparticles and vascular disease. In Atherosclerosis Disease Management (pp. 749-763). Springer New York. https://doi.org/10.1007/978-1-4419-7222-4_24