Biologic factors associated with tumor oxygenation are prognostic in patients with stage III esophageal cancer: Long-term results

Dirk Rades, Amira Bajrovic, Steven E. Schild, Christoph Thorns, Ergin Kilic

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background/Aim: Long-term results of a study investigating potential prognostic factors for treatment outcomes in patients with stage III esophageal cancer are presented. Patients and Methods: In 64 patients, the impact of tumor cell expression of erythropoietin (EPO) and erythropoietin-receptor (EPO-R) and ten additional factors (age, gender, performance status, tumor length, tumor stage (T-stage), nodes (N-stage), histology/grading, hemoglobin levels during radiotherapy, surgery) on survival and locoregional control was evaluated up to 10 years following radio-chemotherapy. Results: On multivariate analysis, improved survival was associated with low EPO-R expression (p=0.034) and hemoglobin levels during radiotherapy ≥12 g/dl (p=0.026). Low EPO expression was associated with survival on univariate (p=0.010) but not on multivariate analysis (p=0.42). On multivariate analysis, improved loco-regional control was significantly associated with hemoglobin levels during radiotherapy ≥12 g/dl (p<0.001). Conclusion: The long-term results confirm that hemoglobin levels during radiotherapy and tumor cell expression of EPO-R are significant prognostic factors in patients with locally advanced esophageal cancer.

Original languageEnglish (US)
Pages (from-to)4351-4356
Number of pages6
JournalAnticancer research
Volume34
Issue number8
StatePublished - Aug 1 2014

Keywords

  • EPO expression
  • EPO-R expression
  • Long-term results
  • Prognostic factors
  • Radio-chemotherapy
  • Stage III esophageal cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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