Biologic activity of rhBMP-2 following release from PLGA microspheres

Jacob B. Oldham, Blaise D. Porter, Theresa E. Hefferan, Bradford L. Currier, Antonios G. Mikos, Michael J Yaszemski

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The encapsulation of rhBMP-2 in polymeric microspheres, as well as its biologic activity upon release were investigated. It was observed that rhBMP-2 can be encapsulated in poly(lactic/glycolic acid) (PLGA) microspheres and that the protein remains active after release from the microspheres.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Place of PublicationFairfield, NJ, United States
PublisherASME
Pages745-746
Number of pages2
Volume42
ISBN (Print)0791816117
StatePublished - 1999
Event1999 Bioengineering Conference - Big Sky, MT, USA
Duration: Jun 16 1999Jun 20 1999

Other

Other1999 Bioengineering Conference
CityBig Sky, MT, USA
Period6/16/996/20/99

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Lactic acid
Microspheres
Encapsulation
Proteins

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Oldham, J. B., Porter, B. D., Hefferan, T. E., Currier, B. L., Mikos, A. G., & Yaszemski, M. J. (1999). Biologic activity of rhBMP-2 following release from PLGA microspheres. In American Society of Mechanical Engineers, Bioengineering Division (Publication) BED (Vol. 42, pp. 745-746). Fairfield, NJ, United States: ASME.

Biologic activity of rhBMP-2 following release from PLGA microspheres. / Oldham, Jacob B.; Porter, Blaise D.; Hefferan, Theresa E.; Currier, Bradford L.; Mikos, Antonios G.; Yaszemski, Michael J.

American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 42 Fairfield, NJ, United States : ASME, 1999. p. 745-746.

Research output: Chapter in Book/Report/Conference proceedingChapter

Oldham, JB, Porter, BD, Hefferan, TE, Currier, BL, Mikos, AG & Yaszemski, MJ 1999, Biologic activity of rhBMP-2 following release from PLGA microspheres. in American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. vol. 42, ASME, Fairfield, NJ, United States, pp. 745-746, 1999 Bioengineering Conference, Big Sky, MT, USA, 6/16/99.
Oldham JB, Porter BD, Hefferan TE, Currier BL, Mikos AG, Yaszemski MJ. Biologic activity of rhBMP-2 following release from PLGA microspheres. In American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 42. Fairfield, NJ, United States: ASME. 1999. p. 745-746
Oldham, Jacob B. ; Porter, Blaise D. ; Hefferan, Theresa E. ; Currier, Bradford L. ; Mikos, Antonios G. ; Yaszemski, Michael J. / Biologic activity of rhBMP-2 following release from PLGA microspheres. American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 42 Fairfield, NJ, United States : ASME, 1999. pp. 745-746
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