TY - JOUR
T1 - Bioinformatic networks
T2 - Molecular reticles for pinpointing pharmacological target selection
AU - Faustino, R. S.
AU - Terzic, A.
PY - 2008/11
Y1 - 2008/11
N2 - Bridging centrality was developed as a novel metric to capitalize on rich biological networks and enable selection of therapeutically efficient, druggable candidates. Through incorporation of local and global network properties, targetable nodes are identified that harbor latent capacity to intercept informational flow without compromising systemic functionality. Translational implementation holds potential for increased therapeutic specificity and offers opportunities to add value to drug discovery and development through facilitation of individualized treatment.
AB - Bridging centrality was developed as a novel metric to capitalize on rich biological networks and enable selection of therapeutically efficient, druggable candidates. Through incorporation of local and global network properties, targetable nodes are identified that harbor latent capacity to intercept informational flow without compromising systemic functionality. Translational implementation holds potential for increased therapeutic specificity and offers opportunities to add value to drug discovery and development through facilitation of individualized treatment.
UR - http://www.scopus.com/inward/record.url?scp=54249135797&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=54249135797&partnerID=8YFLogxK
U2 - 10.1038/clpt.2008.181
DO - 10.1038/clpt.2008.181
M3 - Comment/debate
C2 - 18941454
AN - SCOPUS:54249135797
SN - 0009-9236
VL - 84
SP - 543
EP - 545
JO - Clinical pharmacology and therapeutics
JF - Clinical pharmacology and therapeutics
IS - 5
ER -